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dc.contributor.authorAl-Daghri, Nasser M.
dc.contributor.authorAbdi, Saba
dc.contributor.authorSabico, Shaun
dc.contributor.authorAlnaami, Abdullah M.
dc.contributor.authorWani, Kaiser A.
dc.contributor.authorAnsari, Mohammed G. A.
dc.contributor.authorKhattak, Malak Nawaz Khan
dc.contributor.authorKhan, Nasiruddin
dc.contributor.authorTripathi, Gyanendra
dc.contributor.authorChrousos, George P.
dc.contributor.authorMcTernan, Philip G.
dc.identifier.citationAl-Daghri, N.M., Abdi, S., Sabico, S., Alnaami, A.M., Wani, K.A., Ansari, M.G., Khattak, M.N.K., Khan, N., Tripathi, G., Chrousos, G.P. and McTernan, P.G., 2021. Gut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetes. Biomolecules, 11(11), pp. 1693-1705.en_US
dc.description.abstractPremature aging, as denoted by a reduced telomere length (TL), has been observed in several chronic inflammatory diseases, such as obesity and type 2 diabetes mellitus (T2DM). However, no study to date has addressed the potential inflammatory influence of the gut-derived Gram-negative bacterial fragments lipopolysaccharide, also referred to as endotoxin, and its influence on TL in low-grade inflammatory states such as type 2 diabetes mellitus (T2DM). The current study therefore investigated the influence of endotoxin and inflammatory factors on telomere length (TL) in adults with (T2DM: n = 387) and without (non-diabetic (ND) controls: n = 417) obesity and T2DM. Anthropometric characteristics were taken, and fasted blood samples were used to measure biomarkers, TL, and endotoxin. The findings from this study highlighted across all participants that circulating endotoxin (r = −0.17, p = 0.01) was inversely associated with TL, noting that endotoxin and triglycerides predicted 18% of the variance perceived in TL (p < 0.001). Further stratification of the participants according to T2DM status and sex highlighted that endotoxin significantly predicted 19% of the variance denoted in TL among male T2DM participants (p = 0.007), where TL was notably influenced. The influence on TL was not observed to be impacted by anti-T2DM medications, statins, or anti-hypertensive therapies. Taken together, these results show that TL attrition was inversely associated with circulating endotoxin levels independent of the presence of T2DM and other cardiometabolic factors, suggesting that low-grade chronic inflammation may trigger premature biological aging. The findings further highlight the clinical relevance of mitigating the levels of circulating endotoxin (e.g., manipulation of gut microbiome) not only for the prevention of chronic diseases but also to promote healthy aging.en_US
dc.description.sponsorshipNational Plan for Science and Technologyen_US
dc.publisherMDPI AGen_US
dc.subjectMolecular Biologyen_US
dc.subjectpremature agingen_US
dc.titleGut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetesen_US
dc.contributor.departmentKing Saud University, Riyadh 11451, Saudi Arabiaen_US
dc.contributor.departmentA’Sharqiyah University, Ibra 400, Omanen_US
dc.contributor.departmentUniversity of Derbyen_US
dc.contributor.departmentNational and Kapodistrian University of Athens, 11527 Athens, Greeceen_US
dc.contributor.departmentNottingham Trent Universityen_US

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