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    Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial.

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    Authors
    Ashton, Ruth E
    Aning, Jonathan J
    Tew, Garry A
    Robson, Wendy A
    Saxton, John M
    Affiliation
    University of Derby
    Bristol Urological Institute, North Bristol NHS Trust, Southmead Hospital, Bristol
    University of Northumbria
    Freeman Hospital, Newcastle-upon-Tyne
    Issue Date
    2021-01-23
    
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    Abstract
    To investigate the effects of a supported home-based progressive resistance exercise training (RET) programme on indices of cardiovascular health, muscular strength and health-related quality of life (HR-QoL) in prostate cancer (PCa) patients after treatment with robot-assisted radical prostatectomy (RARP). This study was a single-site, two-arm randomised controlled trial, with 40 participants randomised to either the intervention or control group over a 10-month period. In addition to receiving usual care, the intervention group completed three weekly RET sessions using resistance bands for 6 months. Participants performed 3 sets of 12–15 repetitions for each exercise, targeting each major muscle group. The control group received usual care only. Brachial artery flow-mediated dilatation (FMD) was the primary outcome and assessed at baseline, 3 and 6 months. Secondary outcomes included body weight, body fat, aerobic fitness, strength and blood-borne biomarkers associated with cardiometabolic risk. There was no significant difference between the groups in FMD at 3 or 6 months. However, there were improvements in aerobic exercise capacity (P < 0.01) and upper- (P < 0.01) and lower-limb (P = 0.01) strength in favour of the RET group at 6 months, accompanied by greater weight loss (P = 0.04) and a reduction in body fat (P = 0.02). Improvements in HRQoL were evident in the RET group at 3 and 6 months via the PCa-specific component of the FACT-P questionnaire (both P < 0.01). Five adverse events and one serious adverse event were reported throughout the trial duration. This study demonstrates that home-based RET is an effective and safe mode of exercise that elicits beneficial effects on aerobic exercise capacity, muscular strength and HR-QoL in men who have undergone RARP.
    Citation
    Ashton, R.E., Aning, J.J., Tew, G.A., Robson, W.A. and Saxton, J.M., (2021). 'Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial'. Supportive Care in Cancer, pp. 1-11.
    Publisher
    Springer
    Journal
    Supportive care in cancer
    URI
    http://hdl.handle.net/10545/625578
    DOI
    10.1007/s00520-021-06002-5
    PubMed ID
    33483790
    Additional Links
    https://link.springer.com/article/10.1007/s00520-021-06002-5
    Type
    Article
    Language
    en
    EISSN
    1433-7339
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00520-021-06002-5
    Scopus Count
    Collections
    School of Human Sciences

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