An iterative run-to-run learning model to derive continuous brachial pressure estimates from arterial and venous lines during dialysis treatment
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Authors
Stewart, JillStewart, Paul
Walker, Tom
Viramontes-Hörner, Daniela
Lucas, Bethany
White, Kelly
Taal, Maarten W.
Selby, Nicholas M.
Morris, Mel
Affiliation
University of DerbyUniversity of Nottingham
Renal unit, Royal Derby Hospital, Derby,
ITREND Medical Research Ltd., UK
Issue Date
2020-11-28
Metadata
Show full item recordAbstract
Objective: Non-invasive continuous blood pressure monitoring is not yet part of routine practice in renal dialysis units but could be a valuable tool in the detection and prevention of significant variations in patient blood pressure during treatment. Feasibility studies have delivered an initial validation of a method which utilises pressure sensors in the extra-corporeal dialysis circuit, without any direct contact with the person receiving treatment. Our main objective is to further develop this novel methodology from its current early development status to a continuous-time brachial artery pressure estimator. Methods: During an in vivo patient feasibility study with concurrent measurement validation by Finapres Nova experimental physiological measurement device, real-time continuous dialysis line pressures, and intermittent occluding arm cuff pressure data were collected over the entire period of (typically 4-hour) dialysis treatments. There was found to be an underlying quasi-linear relationship between arterial line and brachial pressure measurements which supported the development of a mathematical function to describe the relationship between arterial dialysis line pressure and brachial artery BP. However, unmodelled non-linearities, dynamics and time-varying parameters present challenges to the development of an accurate BP estimation system. In this paper, we start to address the problem of physiological parameter time variance by novel application of an iterative learning run-to-run modelling methodology originally developed for process control engineering applications to a parameterised BP model. Results: The iterative run-to-run learning methodology was applied to the real-time data measured during an observational study in 9 patients, supporting subsequent development of an adaptive real-time BP estimator. Tracking of patient BP is analysed for all the subjects in our patient study, supported only by intermittent updates from BP cuff measurements. Conclusion: The methodology and associated technology is shown to be capable of tracking patient BP noninvasively via arterial line pressure measurement during complete 4-hour treatment sessions. A robust and tractable method is demonstrated, and future refinements to the approach are defined.Citation
Stewart, J., Stewart, P., Walker, T., Viramontes-Hörner, D., Lucas, B., White, K., Taal, M.W., Selby, N.M. and Morris, M., (2020). 'An iterative run-to-run learning model to derive continuous brachial pressure estimates from arterial and venous lines during dialysis treatment'. Biomedical Signal Processing and Control, 65, pp. 1-8.Publisher
Elsevier BVJournal
Biomedical Signal Processing and ControlDOI
10.1016/j.bspc.2020.102346Type
ArticleLanguage
enISSN
1746-8094ae974a485f413a2113503eed53cd6c53
10.1016/j.bspc.2020.102346
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons