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dc.contributor.authorDias, Irundika H.K.
dc.contributor.authorMilic, Ivana
dc.contributor.authorHeiss, Christian
dc.contributor.authorAdemowo, Opeyemi S.
dc.contributor.authorPolidori, Maria Cristina
dc.contributor.authorDevitt, Andrew
dc.contributor.authorGriffiths, Helen R.
dc.date.accessioned2020-04-01T16:03:31Z
dc.date.available2020-04-01T16:03:31Z
dc.date.issued2020-02-28
dc.identifier.citationDias, I.H., Milic, I., Heiss, C., Ademowo, O.S., Polidori, M.C., Devitt, A. and Griffiths, H.R., (2020). Inflammation, lipid (per) oxidation, and redox regulation’. Antioxidants & Redox Signaling, 33, pp. 1-46.en_US
dc.identifier.issn1523-0864
dc.identifier.doi10.1089/ars.2020.8022
dc.identifier.urihttp://hdl.handle.net/10545/624647
dc.description.abstractSignificance: Inflammation increases during the aging process. It is linked to mitochondrial dysfunction and increased reactive oxygen species (ROS) production. Mitochondrial macromolecules are critical targets of oxidative damage; they contribute to respiratory uncoupling with increased ROS production, redox stress, and a cycle of senescence, cytokine production, and impaired oxidative phosphorylation. Targeting the formation or accumulation of oxidized biomolecules, particularly oxidized lipids, in immune cells and mitochondria could be beneficial for age-related inflammation and comorbidities. Recent Advances: Inflammation is central to age-related decline in health and exhibits a complex relationship with mitochondrial redox state and metabolic function. Improvements in mass spectrometric methods have led to the identification of families of oxidized phospholipids (OxPLs), cholesterols, and fatty acids that increase during inflammation and which modulate nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor gamma (PPARγ), activator protein 1 (AP1), and NF-κB redox-sensitive transcription factor activity. Critical Issues: The kinetic and spatial resolution of the modified lipidome has profound and sometimes opposing effects on inflammation, promoting initiation at high concentration and resolution at low concentration of OxPLs. Future Directions: There is an emerging opportunity to prevent or delay age-related inflammation and vascular comorbidity through a resolving (oxy)lipidome that is dependent on improving mitochondrial quality control and restoring redox homeostasis.en_US
dc.description.sponsorshipOSA was supported by the Aston Research Centre for Healthy Ageing. HKID and HRG gratefully acknowledge support from the Kidney Research Foundation PDF3/2014.en_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert Incen_US
dc.relation.urlhttps://www.liebertpub.com/doi/abs/10.1089/ars.2020.8022en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectClinical Biochemistryen_US
dc.subjectCell Biologyen_US
dc.subjectBiochemistryen_US
dc.subjectPhysiologyen_US
dc.subjectMolecular Biologyen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectEicosanoidsen_US
dc.subjectMetabolismen_US
dc.subjectOxidized phospholipidsen_US
dc.subjectOxysterolsen_US
dc.subjectReactive oxygen species.en_US
dc.titleInflammation, lipid (per)oxidation, and redox regulationen_US
dc.typeArticleen_US
dc.identifier.eissn1557-7716
dc.contributor.departmentAston University, Birmingham, West Midlands, UKen_US
dc.contributor.departmentUniversity of Surreyen_US
dc.contributor.departmentUniversity of Cologneen_US
dc.identifier.journalAntioxidant and Redox Signalingen_US
dc.identifier.pii10.1089/ars.2020.8022
dc.source.journaltitleAntioxidants & Redox Signaling
dcterms.dateAccepted2020-01
dc.author.detail300514en_US


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