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Inflammation_ARSfinalrev_OS ...
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7.705Mb
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Microsoft Word 2007
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Accepted Manuscript
Authors
Dias, Irundika H.K.Milic, Ivana
Heiss, Christian
Ademowo, Opeyemi S.
Polidori, Maria Cristina
Devitt, Andrew
Griffiths, Helen R.
Affiliation
Aston University, Birmingham, West Midlands, UKUniversity of Surrey
University of Cologne
Issue Date
2020-02-28
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Show full item recordAbstract
Significance: Inflammation increases during the aging process. It is linked to mitochondrial dysfunction and increased reactive oxygen species (ROS) production. Mitochondrial macromolecules are critical targets of oxidative damage; they contribute to respiratory uncoupling with increased ROS production, redox stress, and a cycle of senescence, cytokine production, and impaired oxidative phosphorylation. Targeting the formation or accumulation of oxidized biomolecules, particularly oxidized lipids, in immune cells and mitochondria could be beneficial for age-related inflammation and comorbidities. Recent Advances: Inflammation is central to age-related decline in health and exhibits a complex relationship with mitochondrial redox state and metabolic function. Improvements in mass spectrometric methods have led to the identification of families of oxidized phospholipids (OxPLs), cholesterols, and fatty acids that increase during inflammation and which modulate nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor gamma (PPARγ), activator protein 1 (AP1), and NF-κB redox-sensitive transcription factor activity. Critical Issues: The kinetic and spatial resolution of the modified lipidome has profound and sometimes opposing effects on inflammation, promoting initiation at high concentration and resolution at low concentration of OxPLs. Future Directions: There is an emerging opportunity to prevent or delay age-related inflammation and vascular comorbidity through a resolving (oxy)lipidome that is dependent on improving mitochondrial quality control and restoring redox homeostasis.Citation
Dias, I.H., Milic, I., Heiss, C., Ademowo, O.S., Polidori, M.C., Devitt, A. and Griffiths, H.R., (2020). Inflammation, lipid (per) oxidation, and redox regulation’. Antioxidants & Redox Signaling, 33, pp. 1-46.Publisher
Mary Ann Liebert IncJournal
Antioxidant and Redox SignalingDOI
10.1089/ars.2020.8022Additional Links
https://www.liebertpub.com/doi/abs/10.1089/ars.2020.8022Type
ArticleLanguage
enISSN
1523-0864EISSN
1557-7716ae974a485f413a2113503eed53cd6c53
10.1089/ars.2020.8022
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