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dc.contributor.authorAdemowo, O. Stella
dc.contributor.authorDias, H. K. Irundika
dc.contributor.authorPararasa, Chathyan
dc.contributor.authorGriffiths, Helen R.
dc.date.accessioned2020-04-01T15:53:57Z
dc.date.available2020-04-01T15:53:57Z
dc.date.issued2018-10-26
dc.identifier.citationAdemowo, O.S., Dias, H.I., Pararasa, C. and Griffiths, H.R., (2019). 'Nutritional hormesis in a modern environment'. In Suresh, I.S.R., and Marios K. (Eds.). 'The Science of Hormesis in Health and Longevity'. Cambridge, Massachusetts: Academic Press, pp. 75-86en_US
dc.identifier.isbn9780128142530
dc.identifier.doi10.1016/b978-0-12-814253-0.00006-1
dc.identifier.urihttp://hdl.handle.net/10545/624646
dc.description.abstractNutrition is a powerful determinant of health and well-being. In the modern environment where energy-rich foods are prevalent, challenges exist to improve diets that will provide an appropriate energy density while maintaining the required nutritional value. A recent concept in nutrition is that components of food which are not abundant in the diet may exert a regulatory effect on physiological and biological processes. Some of these components appear to act as hormetins, i.e., they exert a mild stress and in turn elicit and adaptive response that offers greater health advantages than the stress itself. Therefore, nutritional hormesis play a vital role in the modern aging population by modulating the susceptibility to diseases. Adequate and appropriate dietary levels of hormetic phytochemicals; polyphenols, carotenoids, sulforaphane, and other bioactive compounds have been recognized as activators of intracellular signaling cascades and modifiers of gene expression with health benefits. Research to date has focused on individual hormetins in isolation, however, the bioavailability, bioaccessibility, and potential for interaction of these compounds in combination through acting on distinct intracellular signaling pathways are of significance in the human body. As the modern world’s population ages chronologically, yet biologically at different rates, it is increasingly important to understand how nutrition and hormetins within the diet could reduce risk for age-associated disease. Further work is needed in the field of nutrigenomics to identify the key biochemical targets that are modifiable by hormetins.en_US
dc.description.sponsorshipN/Aen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/B9780128142530000061en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNutritionen_US
dc.subjectPhytochemicalsen_US
dc.subjectHormesisen_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidanten_US
dc.subjectCarotenoidsen_US
dc.subjectPolyphenolsen_US
dc.titleNutritional hormesis in a modern environmenten_US
dc.typeBook chapteren_US
dc.contributor.departmentAston Universityen_US
dc.contributor.departmentUniversity of Surreyen_US
dc.source.booktitleThe Science of Hormesis in Health and Longevity
dc.source.beginpage75
dc.source.endpage86
dcterms.dateAccepted2018
dc.author.detail300514en_US


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