Show simple item record

dc.contributor.authorParthsarathy, Vadivel
dc.contributor.authorMclaughlin, Christopher
dc.contributor.authorHarnedy, Padraigin
dc.contributor.authorAllsopp, Phillip
dc.contributor.authorCrowe, William
dc.contributor.authorMcSorley, Emeir
dc.contributor.authorFitzGerald, Dick
dc.contributor.authorO'Harte, Finbarr
dc.date.accessioned2020-04-01T15:42:30Z
dc.date.available2020-04-01T15:42:30Z
dc.date.issued2018-10-16
dc.identifier.citationParthsarathy, V., McLaughlin, C.M., Harnedy, P.A., Allsopp, P.J., Crowe, W., McSorley, E.M., FitzGerald, R.J. and O’Harte, F.P.M. (2018). 'Boarfish (Capros aper) protein hydrolysate has potent insulinotropic and GLP‐1 secretory activity in vitro and acute glucose lowering effects in mice'. International Journal of Food Science & Technology, 54 (1), pp. 271-281.en_US
dc.identifier.issn09505423
dc.identifier.doi10.1111/ijfs.2019.54.issue-1
dc.identifier.doihttps://doi.org/10.1111/ijfs.13975
dc.identifier.urihttp://hdl.handle.net/10545/624645
dc.description.abstractThe anti‐diabetic actions of a boarfish protein hydrolysate (BPH) were investigated in cultured cells and mice. A boarfish (Capros aper) muscle protein hydrolysate was generated using the enzymes Alcalase 2.4 L and Flavourzyme 500 L. Furthermore, the BPH was subjected to simulated gastrointestinal digestion (SGID). BPH and SGID samples (0.01–2.5 mg mL−1) were tested in vitro for DPP‐IV inhibition and insulin and GLP‐1 secretory activity from BRIN‐BD11 and GLUTag cells, respectively. The BPH and SGID samples, caused a dose‐dependent increase (4.2 to 5.3‐fold, P < 0.001) in insulin secretion from BRIN‐BD11 cells and inhibited DPP‐IV activity (IC50 1.18 ± 0.04 and 1.21 ± 0.04 mg mL−1), respectively. The SGID sample produced a 1.3‐fold (P < 0.01) increase in GLP‐1 secretion. An oral glucose tolerance test (OGTT) was conducted in healthy mice (n = 8), with or without BPH (50 mg/kg bodyweight). BPH mediated an increase in plasma insulin levels (AUC(0–120 min), P < 0.05) and a consequent reduction in blood glucose concentration (P < 0.01), after OGTT in mice versus controls. The BPH showed potent anti‐diabetic actions in cells and improved glucose tolerance in mice.en_US
dc.description.sponsorshipFood Institutional Research Measure Department of Agriculture, Food and the Marine, Ireland. Grant Numbers: 11/F/063, 11/F/064, 13/F/467, 13/F/536, 14/F/873 Science Foundation Ireland Infrastructure Fund Higher Education Authority under the Programme for Research in Third Level Institutionsen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttp://doi.wiley.com/10.1111/ijfs.2019.54.issue-1en_US
dc.relation.urlhttps://pure.ulster.ac.uk/en/publications/boarfish-capros-aper-protein-hydrolysate-has-potent-insulinotropien_US
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectBoarfish protein hydrolysateen_US
dc.subjectdipeptidyl peptidase-IV inhibitionen_US
dc.subjectGlucagon-like peptide-1en_US
dc.subjectglycaemic control in miceen_US
dc.subjectinsulin secretionen_US
dc.titleBoarfish (Capros aper) protein hydrolysate has potent insulinotropic and GLP‐1 secretory activity in vitro and acute glucose lowering effects in miceen_US
dc.typeArticleen_US
dc.contributor.departmentUniversity of Ulsteren_US
dc.contributor.departmentUniversity of Limericken_US
dc.identifier.journalInternational Journal of Food Science and Technologyen_US
dc.source.journaltitleInternational Journal of Food Science & Technology
dc.source.volume54
dc.source.issue1
dcterms.dateAccepted2018-09-10
dc.author.detail785773en_US


This item appears in the following Collection(s)

Show simple item record

CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal