Show simple item record

dc.contributor.authorParthsarathy, Vadivel
dc.contributor.authorHogg, Christopher
dc.contributor.authorFlatt, Peter R.
dc.contributor.authorO'Harte, Finbarr P. M.
dc.date.accessioned2020-04-01T09:15:56Z
dc.date.available2020-04-01T09:15:56Z
dc.date.issued2017-07-20
dc.identifier.citationParthsarathy, V., Hogg, C., Flatt, P., and O'Harte, F. (2017). 'Beneficial long-term antidiabetic actions of N- and C-terminally modified analogues of apelin-13 in diet-induced obese diabetic mice'. Diabetes Obesity and Metabolism, 20 (2). pp. 319-327.en_US
dc.identifier.issn14628902
dc.identifier.doi10.1111/dom.13068
dc.identifier.urihttp://hdl.handle.net/10545/624633
dc.description.abstractTo investigate the chronic effects of twice-daily administration of stable apelin analogues, apelin-13 amide and pyroglutamyl (pGlu) apelin-13 amide, on metabolic variables in glucose-intolerant and insulin-resistant diet-induced obese mice fed a high-fat diet for 150 days. Groups of mice received twice-daily (9 am and 5 pm) injections of saline vehicle, apelin-13 amide, (pGlu)apelin-13 amide or exendin-4(1-39) for 28 days (all at 25 nmol/kg). Energy intake, body weight, non-fasting blood glucose, plasma insulin, glucose tolerance, metabolic response to feeding and insulin sensitivity, together with pancreatic hormone content and biochemical variables such as lipids and total GLP-1 were monitored. Dual-energy X-ray absorptiometry analysis and indirect calorimetry were also performed. Administration of apelin-13 amide, (pGlu)apelin-13 amide or exendin-4 significantly decreased body weight, food intake and blood glucose and increased plasma insulin compared with high-fat-fed saline-treated controls (P < .05 and P < .001), Additionally, all peptide-treated groups exhibited improved glucose tolerance (oral and intraperitoneal), metabolic responses to feeding and associated insulin secretion. (pGlu)apelin-13 amide also significantly improved glycated haemoglobin and insulin sensitivity after 28 days. Both (pGlu)apelin-13 amide and exendin-4 increased bone mineral content and decreased respiratory exchange ratio, whereas only (pGlu)apelin-13 amide increased energy expenditure. All treatment groups displayed reduced circulating triglycerides and increased glucagon-like peptide-1 concentrations, although only (pGlu)apelin-13 amide significantly reduced LDL cholesterol and total body fat, and increased pancreatic insulin content. These data indicate the therapeutic potential of stable apelin-13 analogues, with effects equivalent to or better than those of exendin-4.en_US
dc.description.sponsorshipThis research was funded from a Department of Education and Learning (DEL) N. Ireland grant to CH and by an Invest Northern Ireland Proof of Concept grant (PoC518) awarded to FOH and PF.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttp://doi.wiley.com/10.1111/dom.13068en_US
dc.relation.urlhttp://uir.ulster.ac.uk/38387/en_US
dc.rightsArchived with thanks to Diabetes, Obesity and Metabolismen
dc.subjectadipokineen_US
dc.subjectapelin analoguesen_US
dc.subjectDiabetesen_US
dc.subjectObesityen_US
dc.subjectsatietyen_US
dc.titleBeneficial long-term antidiabetic actions of N- and C-terminally modified analogues of apelin-13 in diet-induced obese diabetic miceen_US
dc.typeArticleen_US
dc.contributor.departmentUniversity of Ulsteren_US
dc.identifier.journalDiabetes, Obesity and Metabolismen_US
dc.contributor.institutionSchool of Biomedical Sciences, SAAD Centre for Pharmacy and Diabetes; University of Ulster; Coleraine Northern Ireland, UK
dc.contributor.institutionSchool of Biomedical Sciences, SAAD Centre for Pharmacy and Diabetes; University of Ulster; Coleraine Northern Ireland, UK
dc.contributor.institutionSchool of Biomedical Sciences, SAAD Centre for Pharmacy and Diabetes; University of Ulster; Coleraine Northern Ireland, UK
dc.contributor.institutionSchool of Biomedical Sciences, SAAD Centre for Pharmacy and Diabetes; University of Ulster; Coleraine Northern Ireland, UK
dcterms.dateAccepted2017-07-01
dc.author.detail785773en_US


This item appears in the following Collection(s)

Show simple item record