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    A 3-month low fat diet leads to significant lipid profile improvement in obese T2DM Saudi subjects, without substantial weight loss, and the capacity to manage a damaging high-fat meal challenge more appropriately post intervention

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    Authors
    Al-Disi, D
    Al-Daghri, N
    Khan, N
    Alsaif, M
    Alfadda, A
    Sabico, S
    Tripathi, G
    McTernan, P
    Affiliation
    University of Westminster
    Issue Date
    01/03/2014
    
    Metadata
    Show full item record
    Abstract
    Current evidence highlights that dietary cholesterol, trans-fatty acids and saturated fatty acids (SFAs) are all known to increase the levels of systemic atherogenic lipoproteins and cardiovascular disease. The aim of this study was to observe the direct effect of dietary change, via a calorie-restricted diet on i) cardio-metabolic profile and ii) a high-fat meal challenge pre- and post-3-month intervention. T2DM subjects (Saudi female, age: 40.50±6.8years, BMI: 37.28±10.75 kg/m2, n=18) were given a high-fat meal pre- and post-calorie restricted diet (3 months; 500 kcal deficit/day, balanced diet with complex carbohydrate). Baseline (0 h) and post-prandial sera (1–4 h) were taken from subjects, anthropometric and biochemical data was collated at both time points. On baseline comparison of pre- and post-diet interventions, there were modest reductions in anthropometric data, BMI (P<0.001), waist (P<0.001), and waist:hip ratio (WHR; P<0.01). Baseline HDL-cholesterol increased significantly (P<0.01) whilst LDL- and total-cholesterol were significantly reduced (pre-total cholesterol: 5.13 (4.53, 5.93) vs post-total cholesterol: 4.70 (4.01, 5.14); pre-LDL cholesterol: 3.56 (3.07, 4.06) vs post-LDL cholesterol: 2.81 (2.34, 3.56), P<0.05). The findings also showed significant changes in the effects of high-fat meal intake on the metabolic profile pre- and post-diet intervention. At 4 h post-prandially, post-dietary intervention, HDL-cholesterol was 16.6% higher than pre-diet (P<0.05), whilst LDL- and total-cholesterol were 24.2 and 12% lower, respectively, than at the 4 h equivalent pre-diet (P<0.05). These findings suggest that lipid mediators associated with increased cardiometabolic risk can be quickly reversed as a result of a balanced diet, in T2DM subjects without substantial weight loss. As a result, the body is able to cope with the occasional high-fat meal insult, whilst still maintaining a reduced long-term CVD risk. As such, this is a diet that patients with T2DM may be able to adhere to more successfully, longer-term.
    Citation
    Al-Disi, D., Al-Daghri, N., Khan, N., Alsaif, M., Alfadda, A., Sabico, S., Tripathi, G. and McTernan, P. (2014). 'A 3-month low fat diet leads to significant lipid profile improvement in obese T2DM Saudi subjects, without substantial weight loss, and the capacity to manage a damaging high-fat meal challenge more appropriately post intervention. Society for Endocrinology BES 2014. Liverpool 24 - 27 May. Society for Endocrinology. DOI :10.1530/endoabs.34.P223.
    Publisher
    bioscientifica
    Journal
    Endocrine Abstracts
    URI
    http://hdl.handle.net/10545/624111
    DOI
    10.1530/endoabs.34.P223
    Additional Links
    https://www.endocrine-abstracts.org/ea/0034/ea0034P223.htm
    Type
    Meetings and proceedings
    Language
    en
    ISSN
    14703947
    EISSN
    14796848
    ae974a485f413a2113503eed53cd6c53
    10.1530/endoabs.34.P223
    Scopus Count
    Collections
    School of Human Sciences

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