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dc.contributor.authorAl-Daghri, N.M
dc.contributor.authorMohammed, A.K
dc.contributor.authorAl-Attas, O.S
dc.contributor.authorAnsari, M.G.A
dc.contributor.authorWani, K
dc.contributor.authorHussain, S.D
dc.contributor.authorSabico, S
dc.contributor.authorTripathi, G
dc.contributor.authorAlokail, M.S
dc.date.accessioned2019-08-09T08:51:00Z
dc.date.available2019-08-09T08:51:00Z
dc.date.issued15/08/2017
dc.identifier.citationAl-Daghri, N.M., Mohammed, A.K., Al-Attas, O.S., Ansari, M.G.A., Wani, K., Hussain, S.D., Sabico, S., Tripathi, G. and Alokail, M.S., (2017). 'Vitamin D receptor Gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients'. Scientific reports, 7(1), pp.1-10. DOI: 10.1038/s41598-017-08621-7.
dc.identifier.doi10.1038/s41598-017-08621-7
dc.identifier.urihttp://hdl.handle.net/10545/624105
dc.description.abstractThere is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months. VDR polymorphisms (Taq-I, Bsm-I, Apa-I and Fok-I) were identified using TaqMan genotyping assays. Vitamin D supplementation significantly increased HOMA β-cell function (p = 0.003) as well as significantly decreased triglycerides, total and LDL-cholesterol (p < 0.001). The lowest increment in 25(OH)D levels was detected in patients with Fok-I CC genotypes (p < 0.0001). With vitamin D supplementation, Taq-I GG genotype carriers showed significant improvements in triglycerides, LDL- and total cholesterol, insulin, HbA1c and HOMA-IR (p < 0.005, 0.01, < 0.001, < 0.005, 0.03 and 0.01, respectively). Similarly, Bsm-I TT genotype carriers showed significant improvements in triglycerides (p = 0.01), insulin and HOMA-IR (p-values < 0.05). In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes.
dc.description.sponsorshipN/A
dc.language.isoen
dc.publisherNature
dc.relation.urlhttps://www.nature.com/articles/s41598-017-08621-7
dc.titleVitamin D receptor gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients
dc.typeArticle
dc.identifier.eissn20452322
dc.contributor.departmentUniversity of Westminster
dc.identifier.journalScientific Reports


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