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    Vitamin D receptor gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients

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    Authors
    Al-Daghri, N.M
    Mohammed, A.K
    Al-Attas, O.S
    Ansari, M.G.A
    Wani, K
    Hussain, S.D
    Sabico, S
    Tripathi, G
    Alokail, M.S
    Affiliation
    University of Westminster
    Issue Date
    15/08/2017
    
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    Abstract
    There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months. VDR polymorphisms (Taq-I, Bsm-I, Apa-I and Fok-I) were identified using TaqMan genotyping assays. Vitamin D supplementation significantly increased HOMA β-cell function (p = 0.003) as well as significantly decreased triglycerides, total and LDL-cholesterol (p < 0.001). The lowest increment in 25(OH)D levels was detected in patients with Fok-I CC genotypes (p < 0.0001). With vitamin D supplementation, Taq-I GG genotype carriers showed significant improvements in triglycerides, LDL- and total cholesterol, insulin, HbA1c and HOMA-IR (p < 0.005, 0.01, < 0.001, < 0.005, 0.03 and 0.01, respectively). Similarly, Bsm-I TT genotype carriers showed significant improvements in triglycerides (p = 0.01), insulin and HOMA-IR (p-values < 0.05). In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes.
    Citation
    Al-Daghri, N.M., Mohammed, A.K., Al-Attas, O.S., Ansari, M.G.A., Wani, K., Hussain, S.D., Sabico, S., Tripathi, G. and Alokail, M.S., (2017). 'Vitamin D receptor Gene polymorphisms modify cardiometabolic response to vitamin D supplementation in T2DM patients'. Scientific reports, 7(1), pp.1-10. DOI: 10.1038/s41598-017-08621-7.
    Publisher
    Nature
    Journal
    Scientific Reports
    URI
    http://hdl.handle.net/10545/624105
    DOI
    10.1038/s41598-017-08621-7
    Additional Links
    https://www.nature.com/articles/s41598-017-08621-7
    Type
    Article
    Language
    en
    EISSN
    20452322
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-017-08621-7
    Scopus Count
    Collections
    School of Human Sciences

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