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    Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects

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    Authors
    Al-Daghri, N.M
    Rahman, S
    Sabico, S
    Yakout, S
    Wani, K
    Al-Attas, O.S
    Saravanan, P
    Tripathi, G
    McTernan, P.G
    Alokail, M.S
    Affiliation
    University of Westminster
    Issue Date
    06/09/2016
    
    Metadata
    Show full item record
    Abstract
    his study aimed to examine the relationship between changes in systemic vitamin B12 concentrations with pro-inflammatory cytokines, anthropometric factors and biochemical markers of cardiometabolic risk in a Saudi population. Methods: A total of 364 subjects (224 children, age: 12.99 ± 2.73 (mean ± SD) years; BMI: 20.07 ± 4.92 kg/m2 and 140 adults, age: 41.87 ± 8.82 years; BMI: 31.65 ± 5.77 kg/m2) were studied. Fasting blood, anthropometric and biochemical data were collected. Serum cytokines were quantified using multiplex assay kits and B12 concentrations were measured using immunoassay analyzer. Results: Vitamin B12 was negatively associated with TNF-α (r = −0.14, p < 0.05), insulin (r = −0.230, p < 0.01) and HOMA-IR (r = −0.252, p < 0.01) in all subjects. In children, vitamin B12 was negatively associated with serum resistin (r = −0.160, p < 0.01), insulin (r = −0.248, p < 0.01), HOMA-IR (r = −0.261, p < 0.01). In adults, vitamin B12 was negatively associated with TNF-α (r = −0.242, p < 0.01) while positively associated with resistin (r = 0.248, p < 0.01). Serum resistin was the most significant predictor for circulating vitamin B12 in all subjects (r2 = −0.17, p < 0.05) and in children (r2 = −0.167, p < 0.01) while HDL-cholesterol was the predictor of B12 in adults (r2 = −0.78, p < 0.05). Conclusions: Serum vitamin B12 concentrations were associated with pro-inflammatory cytokines and biochemical markers of cardiometabolic risks in adults. Maintaining adequate vitamin B12 concentrations may lower inflammation-induced cardiometabolic risk in the Saudi adult population.
    Citation
    Al-Daghri, N., Rahman, S., Sabico, S., et al. (2016). 'Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects'. nutrients, 8(9), pp. 1-8. DOI: 10.3390/nu8090460
    Publisher
    MDPI
    Journal
    Nutrients
    URI
    http://hdl.handle.net/10545/624099
    DOI
    10.3390/nu8090460
    Additional Links
    https://www.mdpi.com/2072-6643/8/9/460
    Type
    Article
    Language
    en
    ISSN
    20726643
    EISSN
    20726643
    ae974a485f413a2113503eed53cd6c53
    10.3390/nu8090460
    Scopus Count
    Collections
    School of Human Sciences

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