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    Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes.

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    Authors
    Hu, J
    Kyrou, I
    Tan, B.K
    Dimitriadis, G.K
    Ramanjaneya, M
    Tripathi, G
    Patel, V
    James, S
    Kawan, M
    Chen, J
    Randeva, H.S
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    Affiliation
    University of Warwick
    Issue Date
    01/05/2016
    
    Metadata
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    Abstract
    Short-chain fatty acids play crucial roles in a range of physiological functions. However, the effects of short-chain fatty acids on brown adipose tissue have not been fully investigated. We examined the role of acetate, a short-chain fatty acid formed by fermentation in the gut, in the regulation of brown adipocyte metabolism. Our results show that acetate up-regulates adipocyte protein 2, peroxisomal proliferator-activated receptor-γ coactivator-1α, and uncoupling protein-1 expression and affects the morphological changes of brown adipocytes during adipogenesis. Moreover, an increase in mitochondrial biogenesis was observed after acetate treatment. Acetate also elicited the activation of ERK and cAMP response element-binding protein, and these responses were sensitive to G(i/o)-type G protein inactivator, Gβγ-subunit inhibitor, phospholipase C inhibitor, and MAPK kinase inhibitor, indicating a role for the G(i/o)βγ/phospholipase C/protein kinase C/MAPK kinase signaling pathway in these responses. These effects of acetate were mimicked by treatment with 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide, a synthetic G protein-coupled receptor 43 (GPR43) agonist and were impaired in GPR43 knockdown cells. Taken together, our results indicate that acetate may have important physiological roles in brown adipocytes through the activation of GPR43.
    Citation
    Hu, J., Kyrou, I., Tan, B.K., Dimitriadis, G.K., Ramanjaneya, M., Tripathi, G., Patel, V., James, S., Kawan, M., Chen, J. and Randeva, H.S., 2016. Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes. Endocrinology, 157(5), pp.1881-1894.
    Publisher
    Oxford Academic
    Journal
    Endocrinology
    URI
    http://hdl.handle.net/10545/624097
    DOI
    10.1210/en.2015-1944
    Additional Links
    https://academic.oup.com/endo/article/157/5/1881/2422634
    Type
    Article
    Language
    en
    ISSN
    137227
    EISSN
    19457170
    ae974a485f413a2113503eed53cd6c53
    10.1210/en.2015-1944
    Scopus Count
    Collections
    School of Human Sciences

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