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dc.contributor.authorAdaikalakoteswari, A
dc.contributor.authorFiner, S
dc.contributor.authorVoyias, P.D
dc.contributor.authorMcCarthy, C.M
dc.contributor.authorVatish, M
dc.contributor.authorMoore, J
dc.contributor.authorSmart-Halajko, M
dc.contributor.authorBawazeer, N
dc.contributor.authorAl-Daghri, N.M
dc.contributor.authorMcTernan, P.G
dc.contributor.authorKumar, S
dc.date.accessioned2019-08-09T08:50:59Z
dc.date.available2019-08-09T08:50:59Z
dc.date.issued27/02/2015
dc.identifier.citationAdaikalakoteswari, A., Finer, S., Voyias, P.D, et al. (2015). 'Vitamin B 12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes'. Clinical epigenetics, 7(1), pp. 1-14. DOI: 10.1186/s13148-015-0046-8
dc.identifier.issn18687083
dc.identifier.doi10.1186/s13148-015-0046-8
dc.identifier.urihttp://hdl.handle.net/10545/624094
dc.description.abstractThe dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and animal studies have shown that vitamin B12 deficiency is associated with altered lipid profile and play an important role in the prediction of metabolic risk, however, as of yet, no direct mechanism has been investigated to confirm this.
dc.description.sponsorshipResearch Councils UK
dc.description.sponsorshipWest Midlands Advantage
dc.description.sponsorshipGeorge Eliot Hospital Diabetes Research Fund
dc.description.sponsorshipWarwick QMUL Collaboration Award
dc.language.isoen
dc.publisherBMC
dc.relation.urlhttps://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0046-8
dc.titleVitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes
dc.typeArticle
dc.contributor.departmentUniversity of Warwick
dc.identifier.journalClinical Epigenetics


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