Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes
AffiliationUniversity of Warwick
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AbstractThe dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and animal studies have shown that vitamin B12 deficiency is associated with altered lipid profile and play an important role in the prediction of metabolic risk, however, as of yet, no direct mechanism has been investigated to confirm this.
CitationAdaikalakoteswari, A., Finer, S., Voyias, P.D, et al. (2015). 'Vitamin B 12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes'. Clinical epigenetics, 7(1), pp. 1-14. DOI: 10.1186/s13148-015-0046-8