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    Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly.

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    Authors
    Reddy, N.L
    Peng, C
    Carreira, M.C
    Halder, L
    Hattersley, J
    Piya, M.K
    Tripathi, G
    Randeva, H.S
    Casanueva, F.F
    McTernan, P.G
    Kumar, S
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    Affiliation
    University of Warwick
    Issue Date
    04/11/2014
    
    Metadata
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    Abstract
    Meal duration may influence cardiometabolic health. The aim of this study was to explore postprandial effects of meal duration on human metabolism and appetite. Postprandial comparisons following a standard meal eaten slowly over 40 min (‘D40’) and the same meal eaten quickly over 10 min (‘D10’) on a different day. Each participant therefore acted as their own control, thereby limiting confounding factors. Obese premenopausal Caucasian women (n = 10) with confirmed normoglycaemia were recruited from an obesity clinic at UHCW, Coventry UK. Subjects underwent whole‐body calorimetry (8‐h) on two separate days. Following standard lunch (D40 vs D10), 4‐h postprandial analysis included thermic effect of food (TEF) and bloods taken at predefined times (including baseline fasting). Analytes included lipid profile, adiponectin, insulin, glucose, ghrelin, leptin, endotoxin, gut and pancreatic hormones. Appetite was measured using visual‐analogue scales and ad libitum food intake at subsequent meal. Paired sample t‐tests [including area under the curve (AUC)] were used to compare D40 and D10 trials. Postprandial TEF (over 240‐min) was significantly greater for D40 than D10 [mean (SEM): 80·9 kcal (3·8) vs 29·9 kcal (3·4); 10·6% vs 3·9%, respectively, P = 0·006; AUC 71·7 kcal.h vs 22·4 kcal.h, respectively, P = 0·02]. Postprandial plasma NEFA was significantly lower, and adiponectin levels were significantly higher for D40 than D10 [AUC (SEM): NEFA 627 μmol.h/l (56) vs 769 μmol.h/l (60), respectively, P = 0·02; adiponectin 33·4 μg.h/ml (3·9) vs 27·3 μg.h/ml (3·8), respectively, P = 0·04]. Other postprandial analytes and appetite measures were equivalent. In obese women, eating slowly associates with enhanced TEF, elevated serum adiponectin and suppressed NEFA.
    Citation
    Reddy, N.L., Peng, C., Carreira, M.C. (2015). 'Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly'. Clinical endocrinology, 82(6), pp.831-837. DOI: 10.1111/cen.12652.
    Publisher
    Wiley
    Journal
    Cinical Endocrinology
    URI
    http://hdl.handle.net/10545/624092
    DOI
    10.1111/cen.12652
    Additional Links
    https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.12652
    Type
    Article
    Language
    en
    ISSN
    3000664
    EISSN
    13652265
    ae974a485f413a2113503eed53cd6c53
    10.1111/cen.12652
    Scopus Count
    Collections
    School of Human Sciences

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