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dc.contributor.authorMarsh, Elizabeth K
dc.contributor.authorMay, Robin C
dc.date.accessioned2019-06-14T12:37:52Z
dc.date.available2019-06-14T12:37:52Z
dc.date.issued2012-03-09
dc.identifier.citationMarsh, E., and May, R. (2012) 'Caenorhabditis elegans, a Model Organism for Investigating Immunity', Applied and Environmental Microbiology, 78(7), pp. 2075-2081. doi: 10.1128/AEM.07486-11.en_US
dc.identifier.issn1098-5336
dc.identifier.pmid22286994
dc.identifier.doi10.1128/AEM.07486-11
dc.identifier.urihttp://hdl.handle.net/10545/623878
dc.description.abstractThe nematode Caenorhabditis elegans has been a powerful experimental organism for almost half a century. Over the past 10 years, researchers have begun to exploit the power of C. elegans to investigate the biology of a number of human pathogens. This work has uncovered mechanisms of host immunity and pathogen virulence that are analogous to those involved during pathogenesis in humans or other animal hosts, as well as novel immunity mechanisms which appear to be unique to the worm. More recently, these investigations have uncovered details of the natural pathogens of C. elegans, including the description of a novel intracellular microsporidian parasite as well as new nodaviruses, the first identification of viral infections of this nematode. In this review, we consider the application of C. elegans to human infectious disease research, as well as consider the nematode response to these natural pathogens.en_US
dc.description.sponsorshipThis work was supported by a Medical Research Council (MRC) studentship award to E.K.M. and by Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/F000138/1.en_US
dc.language.isoenen_US
dc.relation.urlhttps://doi.org/10.1128/AEM.07486-11en_US
dc.relation.urlhttps://research.birmingham.ac.uk/portal/en/publications/caenorhabditis-elegans-a-model-organism-for-investigating-immunity(6146fb52-ffd7-40cd-90aa-aeb5a70af4be).htmlen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectC. elegansen_US
dc.subjectInnate Immunityen_US
dc.titleCaenorhabditis elegans, a model organism for investigating immunity.en_US
dc.typeArticleen_US
dc.contributor.departmentUniversity of Birminghamen_US
dc.identifier.journalApplied and Environmental Microbiologyen_US
dc.source.journaltitleApplied and environmental microbiology
dcterms.dateAccepted2012-01-27
dc.author.detail785801en_US


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