Caenorhabditis elegans, a model organism for investigating immunity.
Abstract
The nematode Caenorhabditis elegans has been a powerful experimental organism for almost half a century. Over the past 10 years, researchers have begun to exploit the power of C. elegans to investigate the biology of a number of human pathogens. This work has uncovered mechanisms of host immunity and pathogen virulence that are analogous to those involved during pathogenesis in humans or other animal hosts, as well as novel immunity mechanisms which appear to be unique to the worm. More recently, these investigations have uncovered details of the natural pathogens of C. elegans, including the description of a novel intracellular microsporidian parasite as well as new nodaviruses, the first identification of viral infections of this nematode. In this review, we consider the application of C. elegans to human infectious disease research, as well as consider the nematode response to these natural pathogens.Citation
Marsh, E., and May, R. (2012) 'Caenorhabditis elegans, a Model Organism for Investigating Immunity', Applied and Environmental Microbiology, 78(7), pp. 2075-2081. doi: 10.1128/AEM.07486-11.Journal
Applied and Environmental MicrobiologyDOI
10.1128/AEM.07486-11PubMed ID
22286994Additional Links
https://doi.org/10.1128/AEM.07486-11https://research.birmingham.ac.uk/portal/en/publications/caenorhabditis-elegans-a-model-organism-for-investigating-immunity(6146fb52-ffd7-40cd-90aa-aeb5a70af4be).html
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ArticleLanguage
enISSN
1098-5336ae974a485f413a2113503eed53cd6c53
10.1128/AEM.07486-11
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