A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
AffiliationUniversity of Birmingham
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AbstractLysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.
CitationMarsh, E.K., van den Berg, M.C., and May, R.C. (2011) 'A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans', PLoS One, 6(3), p.e16839. doi: 10.1371/journal.pone.0016839.
PublisherPublic Library of Science
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