A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
AffiliationUniversity of Birmingham
MetadataShow full item record
AbstractLysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.
CitationMarsh, E.K., van den Berg, M.C., and May, R.C. (2011) 'A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans', PLoS One, 6(3), p.e16839. doi: 10.1371/journal.pone.0016839.
PublisherPublic Library of Science
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States
- Resistance to antimicrobial peptides contributes to persistence of Salmonella typhimurium in the C. elegans intestine.
- Authors: Alegado RA, Tan MW
- Issue date: 2008 Jun
- Identification of virulence properties in Salmonella Typhimurium DT104 using Caenorhabditis elegans.
- Authors: Sahu SN, Anriany Y, Grim CJ, Kim S, Chang Z, Joseph SW, Cinar HN
- Issue date: 2013
- A protocol to infect Caenorhabditis elegans with Salmonella typhimurium.
- Authors: Zhang J, Jia K
- Issue date: 2014 Jun 26
- Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis.
- Authors: Boehnisch C, Wong D, Habig M, Isermann K, Michiels NK, Roeder T, May RC, Schulenburg H
- Issue date: 2011
- Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance.
- Authors: Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, Gilpin C, Levine B
- Issue date: 2009 Aug 25