Show simple item record

dc.contributor.authorFretwell, Laurice
dc.contributor.authorWoolard, Jeanette
dc.contributor.authorCarter, Joanne
dc.date.accessioned2019-02-21T16:27:57Z
dc.date.available2019-02-21T16:27:57Z
dc.date.issued2016-12-16
dc.identifier.citationWoolard, J., et al. (2016) 'Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats'. The FASEB Journal, 31(3), pp.1193-1203. DOI: 10.1096/fj.201600749Ren_US
dc.identifier.issn1530-6860
dc.identifier.pmid27986807
dc.identifier.doi10.1096/fj.201600749R
dc.identifier.urihttp://hdl.handle.net/10545/623515
dc.description.abstractVEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms involved, we evaluated their regional hemodynamic effects in conscious rats. Male Sprague Dawley rats (350-450 g) were chronically implanted with pulsed Doppler flow probes (renal and mesenteric arteries, and the descending abdominal aorta) and catheters (jugular vein, peritoneal cavity, and distal abdominal aorta). Regional hemodynamics were measured over 4 d, before and after daily administration of cediranib (3 and 6 mg/kg, 3 and 6 mg/kg/h for 1 h, i.v.), sorafenib (10 and 20 mg/kg, 10 and 20 mg kg/h for 1 h, i.v.), pazopanib (30 and100 mg/kg, i.p.), or vandetanib (12.5 and 25 mg/kg, i.p.). All drugs evoked significant increases.en_US
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (Grant BB/L19418)en_US
dc.language.isoenen_US
dc.publisherFASEBen_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295730/en_US
dc.subjectCancer therapyen_US
dc.subjectRKTIen_US
dc.subjectVEGFen_US
dc.subjectHypertensionen_US
dc.subjectRegional haemodynamicsen_US
dc.titleEffects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats.en_US
dc.typeArticleen_US
dc.contributor.departmentDe Montfort University, Leicesteren_US
dc.contributor.departmentUniversity of Nottinghamen_US
dc.identifier.journalThe FASEB Journalen_US
dc.source.journaltitleFASEB journal : official publication of the Federation of American Societies for Experimental Biology
dcterms.dateAccepted2016-12-03
refterms.dateFOA2019-02-21T16:27:58Z


Files in this item

Thumbnail
Name:
fj.201600749r.pdf
Size:
1.606Mb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record