Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats.
Abstract
VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms involved, we evaluated their regional hemodynamic effects in conscious rats. Male Sprague Dawley rats (350-450 g) were chronically implanted with pulsed Doppler flow probes (renal and mesenteric arteries, and the descending abdominal aorta) and catheters (jugular vein, peritoneal cavity, and distal abdominal aorta). Regional hemodynamics were measured over 4 d, before and after daily administration of cediranib (3 and 6 mg/kg, 3 and 6 mg/kg/h for 1 h, i.v.), sorafenib (10 and 20 mg/kg, 10 and 20 mg kg/h for 1 h, i.v.), pazopanib (30 and100 mg/kg, i.p.), or vandetanib (12.5 and 25 mg/kg, i.p.). All drugs evoked significant increases.Citation
Woolard, J., et al. (2016) 'Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats'. The FASEB Journal, 31(3), pp.1193-1203. DOI: 10.1096/fj.201600749RPublisher
FASEBJournal
The FASEB JournalDOI
10.1096/fj.201600749RPubMed ID
27986807Additional Links
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295730/Type
ArticleLanguage
enISSN
1530-6860ae974a485f413a2113503eed53cd6c53
10.1096/fj.201600749R
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