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    Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats.

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    Authors
    Fretwell, Laurice
    Woolard, Jeanette
    Carter, Joanne
    Affiliation
    De Montfort University, Leicester
    University of Nottingham
    Issue Date
    2016-12-16
    
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    Abstract
    VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms involved, we evaluated their regional hemodynamic effects in conscious rats. Male Sprague Dawley rats (350-450 g) were chronically implanted with pulsed Doppler flow probes (renal and mesenteric arteries, and the descending abdominal aorta) and catheters (jugular vein, peritoneal cavity, and distal abdominal aorta). Regional hemodynamics were measured over 4 d, before and after daily administration of cediranib (3 and 6 mg/kg, 3 and 6 mg/kg/h for 1 h, i.v.), sorafenib (10 and 20 mg/kg, 10 and 20 mg kg/h for 1 h, i.v.), pazopanib (30 and100 mg/kg, i.p.), or vandetanib (12.5 and 25 mg/kg, i.p.). All drugs evoked significant increases.
    Citation
    Woolard, J., et al. (2016) 'Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats'. The FASEB Journal, 31(3), pp.1193-1203. DOI: 10.1096/fj.201600749R
    Publisher
    FASEB
    Journal
    The FASEB Journal
    URI
    http://hdl.handle.net/10545/623515
    DOI
    10.1096/fj.201600749R
    PubMed ID
    27986807
    Additional Links
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295730/
    Type
    Article
    Language
    en
    ISSN
    1530-6860
    ae974a485f413a2113503eed53cd6c53
    10.1096/fj.201600749R
    Scopus Count
    Collections
    School of Human Sciences

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