• Login
    View Item 
    •   Home
    • Research Publications
    • Research Centres & Groups
    • Human Sciences Research Centre
    • View Item
    •   Home
    • Research Publications
    • Research Centres & Groups
    • Human Sciences Research Centre
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UDORACommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About and further information

    AboutOpen Access WebpagesOpen Access PolicyTake Down Policy Quick Guide for Submissions - Doctoral StudentsUniversity NewsTools for ResearchersLibraryUDo

    Statistics

    Display statistics

    Identification and characterisation of NANOG+/ OCT-4<sup>high</sup>/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    24151-338506-7-PB - Oncotarget.pdf
    Size:
    4.168Mb
    Format:
    PDF
    Description:
    Publisher's PDF
    Download
    Authors
    Balahmar, Reham M.
    Boocock, David J.
    Coveney, Clare
    Ray, Sankalita
    Vadakekolathu, Jayakumar
    Regad, Tarik
    Ali, Selman
    Sivasubramaniam, Shiva
    Affiliation
    Nottingham Trent University
    Issue Date
    2018-01-11
    
    Metadata
    Show full item record
    Abstract
    Treatment of gestational trophoblastic diseases (GTD) involves surgery, radiotherapy and chemotherapy. Although, these therapeutic approaches are highly successful, drug resistance and toxicity remain a concern for high risk patients. This Chemoresistance has also been observed in the presence of cancer stem cells that are thought to be responsible for cases of cancer recurrence. In this study, we report the presence of previously unknown populations of trophoblastic stem-like cells (SLCs) that are resistant to the chemotherapeutic drug doxorubicin. We demonstrate that these populations express the stem cell markers NANOG and Sox2 and higher levels of OCT-4 (NANOG+/OCT-4high/SOX2+). Although chemoresistant, we show that the invasive capacity of these trophoblastic SLCs is significantly inhibited by doxorubicin treatment. To better characterise these populations, we also identified cellular pathways that are involved in SLCs-chemoresistance to doxorubicin. In summary, we provide evidence of the presence of NANOG+/OCT-4+/SOX2+ trophoblastic SLCs that are capable to contribute to the susceptibility to GTD and that may be involved in Chemoresistance associated with drug resistance and recurrence in high risk GTDs’ patients. We propose that targeting these populations could be therapeutically exploited for clinical benefit.
    Citation
    Balahmar, R.M., et al. (2018). ‘Identification and characterisation of NANOG+/OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines’. Oncotarget, 9(6), pp. 7054-7065
    Publisher
    Impact Journals
    Journal
    Oncotarget
    URI
    http://hdl.handle.net/10545/623288
    DOI
    10.18632/oncotarget.24151
    Additional Links
    http://www.oncotarget.com/fulltext/24151
    Type
    Article
    Language
    en
    ISSN
    1949-2553
    ae974a485f413a2113503eed53cd6c53
    10.18632/oncotarget.24151
    Scopus Count
    Collections
    Human Sciences Research Centre

    entitlement

     
    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.