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dc.contributor.authorSaeed, Hiwa K.
dc.contributor.authorJarman, Paul J.
dc.contributor.authorArcher, Stuart
dc.contributor.authorSreedharan, Sreejesh
dc.contributor.authorSaeed, Ibrahim Q.
dc.contributor.authorMckenzie, Luke K.
dc.contributor.authorWeinstein, Julia A.
dc.contributor.authorBuurma, Niklaas J.
dc.contributor.authorSmythe, Carl G. W.
dc.contributor.authorThomas, Jim A.
dc.date.accessioned2018-10-18T15:58:27Z
dc.date.available2018-10-18T15:58:27Z
dc.date.issued2017-09-27
dc.identifier.citationSaeed, H. K. et al. (2017) ‘Homo‐ and heteroleptic phototoxic dinuclear metallo‐intercalators based on Ru II(dppn) intercalating moieties: synthesis, optical and biological studies’, Angewandte Chemie International Edition. doi: 10.1002/anie.201707350en
dc.identifier.issn1433-7851
dc.identifier.doi10.1002/anie.201707350
dc.identifier.urihttp://hdl.handle.net/10545/623058
dc.description.abstractUsing a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light‐switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.
dc.description.sponsorshipEPSRC, The University of Sheffielden
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://doi.wiley.com/10.1002/anie.201707350en
dc.rightsArchived with thanks to Angewandte Chemie International Editionen
dc.subjectOrganometallic chemistryen
dc.subjectPhotochemistryen
dc.subjectBioinorganic chemistryen
dc.subjectDnaen
dc.titleHomo‐ and heteroleptic phototoxic dinuclear metallo‐intercalators based on Ru II(dppn) intercalating moieties: synthesis, optical and biological studies.en
dc.typeArticleen
dc.contributor.departmentUniversity of Sheffielden
dc.contributor.departmentCardiff Universityen
dc.identifier.journalAngewandte Chemie International Editionen
dc.contributor.institutionDepartment of Chemistry; University of Sheffield; Sheffield S3 7HF UK
dc.contributor.institutionDepartment of Chemistry; University of Sheffield; Sheffield S3 7HF UK
dc.contributor.institutionDepartment of Chemistry; University of Sheffield; Sheffield S3 7HF UK
dc.contributor.institutionDepartment of Chemistry; University of Sheffield; Sheffield S3 7HF UK
dc.contributor.institutionPhysical Organic Chemistry Centre; School of Chemistry; Cardiff University; Main Building, Park Place Cardiff CF10 3AT UK
dc.contributor.institutionDepartment of Chemistry; University of Sheffield; Sheffield S3 7HF UK
dc.contributor.institutionDepartment of Chemistry; University of Sheffield; Sheffield S3 7HF UK
dc.contributor.institutionPhysical Organic Chemistry Centre; School of Chemistry; Cardiff University; Main Building, Park Place Cardiff CF10 3AT UK
dc.contributor.institutionDepartment of Biomedical Science; University of Sheffield; Sheffield S10 2TN UK
dc.contributor.institutionDepartment of Chemistry; University of Sheffield; Sheffield S3 7HF UK
refterms.dateFOA2019-02-28T17:38:58Z
html.description.abstractUsing a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light‐switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.


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