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dc.contributor.authorTallis, Jason
dc.contributor.authorHiggins, Matthew F.
dc.contributor.authorCox, Val M
dc.contributor.authorDuncan, Michael J
dc.contributor.authorJames, Rob S
dc.date.accessioned2018-10-02T13:45:18Z
dc.date.available2018-10-02T13:45:18Z
dc.date.issued2018-09-17
dc.identifier.citationTallis, J. et al. (2018) ‘An exercise-induced improvement in isolated skeletal muscle contractility does not affect the performance-enhancing benefit of 70μM caffeine treatment’, J. Exp. Biol.en
dc.identifier.issn1477-9145
dc.identifier.pmid30224369
dc.identifier.doi10.1242/jeb.190132
dc.identifier.urihttp://hdl.handle.net/10545/623008
dc.description.abstractThis study aimed to examine the effects of exercise-induced increases in skeletal muscle contractile performance on isolated skeletal muscle caffeine sensitivity. 30-week old CD1 mice (n=28) either acted as controls or underwent eight weeks of voluntary wheel running. Following the treatment intervention, whole soleus (SOL) or a section of the costal diaphragm (DIA) was isolated from each mouse and tested to determine the effect of 70μM caffeine on work loop power output. Although caffeine elicited a significant increase in power of both the SOL and the DIA, relative to a non-caffeine control, the effect was not different between the experimental groups, despite the muscles of the trained group producing significantly greater muscle power. There was no significant relationship between training volume or baseline work loop power and the caffeine response. These results indicate that an exercise-induced increase in muscle performance did not influence the performance-enhancing effects of caffeine.
dc.description.sponsorshipN/Aen
dc.language.isoenen
dc.publisherThe Company of Biologists Ltd.en
dc.relation.urlhttps://jeb.biologists.org/content/221/21/jeb190132
dc.rightsArchived with thanks to The Journal of experimental biologyen
dc.subjectCaffeineen
dc.subjectSkeletal muscleen
dc.titleAn exercise-induced improvement in isolated skeletal muscle contractility does not affect the performance-enhancing benefit of 70μM caffeine treatment.en
dc.typeArticleen
dc.contributor.departmentDerby Universityen
dc.contributor.departmentCoventry Universityen
dc.identifier.journalThe Journal of Experimental Biologyen
dcterms.dateAccepted2018-09-11
html.description.abstractThis study aimed to examine the effects of exercise-induced increases in skeletal muscle contractile performance on isolated skeletal muscle caffeine sensitivity. 30-week old CD1 mice (n=28) either acted as controls or underwent eight weeks of voluntary wheel running. Following the treatment intervention, whole soleus (SOL) or a section of the costal diaphragm (DIA) was isolated from each mouse and tested to determine the effect of 70μM caffeine on work loop power output. Although caffeine elicited a significant increase in power of both the SOL and the DIA, relative to a non-caffeine control, the effect was not different between the experimental groups, despite the muscles of the trained group producing significantly greater muscle power. There was no significant relationship between training volume or baseline work loop power and the caffeine response. These results indicate that an exercise-induced increase in muscle performance did not influence the performance-enhancing effects of caffeine.


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