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    Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties

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    Authors
    Harnedy, Pàdraigín A.
    Parthsarathy, Vadivel cc
    McLaughlin, Chris M.
    O'Keeffe, Martina B.
    Allsopp, Philip J.
    McSorley, Emeir M.
    O'Harte, Finbarr P. M.
    Fitzgerald, Richard J.
    Issue Date
    2017-10-29
    
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    Abstract
    A blue whiting (Micromesistius poutassou) protein hydrolysate generated using Alcalase 2.4L and Flavourzyme 500L and its simulated gastrointestinal digestion (SGID) sample was assessed for antidiabetic potential in vitro and in vivo. In addition to inhibiting dipeptidyl peptidase-IV (DPP–IV), the hydrolysates mediated insulin and glucagon-like peptide-1 (GLP-1) release from BRIN-BD11 and GLUTag cells, respectively. No significant difference was observed in insulinotropic and DPP-IV inhibitory activity following SGID, while GLP-1 secretion increased significantly (p < 0.01). SGID resulted in a significant increase in membrane potential, intracellular calcium and cyclic AMP concentration (p < 0.001) versus a glucose control, indicating that insulin secretion may be mediated by the KATP channel-dependent and the protein kinase A pathways. Additionally, acute (90–120min) and persistent (4h) glucose-lowering effects of the blue whiting hydrolysate were observed in normal healthy mice. These results demonstrate that the blue whiting protein hydrolysate had significant metabolic effects relevant to glucose control in vivo.
    Citation
    Harnedy, PA, Parthsarathy, Vadivel, McLaughlin, CM, O'Keefe, MB, Allsopp, Philip,McSorley, E. M., O'Harte, Finbarr and Fitzgerald, RJ (2017) Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties. Journal of Functional Foods, 40 . pp. 137-145.
    Publisher
    Elsevier
    Journal
    Journal of Functional Foods
    URI
    http://hdl.handle.net/10545/622901
    DOI
    10.1016/j.jff.2017.10.045
    Additional Links
    http://uir.ulster.ac.uk/39112/
    Type
    Journal article
    ISSN
    1756-4646
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jff.2017.10.045
    Scopus Count
    Collections
    Environmental Sustainability Research Centre

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