Controlled antenatal thyroid screening II: Effect of treating maternal suboptimal thyroid function on child cognition.
dc.contributor.author | Hales, Charlotte | |
dc.contributor.author | Taylor, Peter N. | |
dc.contributor.author | Channon, Sue | |
dc.contributor.author | Paradice, Ruth | |
dc.contributor.author | McEwan, Kirsten | |
dc.contributor.author | Zhang, Lei | |
dc.contributor.author | Gyedu, Michael | |
dc.contributor.author | Bakhsh, Ameen | |
dc.contributor.author | Okosieme, Onyebuchi | |
dc.contributor.author | Muller, Ilaria | |
dc.contributor.author | Draman, Mohd S. | |
dc.contributor.author | Gregory, John W. | |
dc.contributor.author | Dayan, Colin | |
dc.contributor.author | Lazarus, John H. | |
dc.contributor.author | Rees, D Aled | |
dc.contributor.author | Ludgate, Marian | |
dc.date.accessioned | 2018-07-27T14:15:20Z | |
dc.date.available | 2018-07-27T14:15:20Z | |
dc.date.issued | 2018-01-15 | |
dc.identifier.citation | Hales, C. et al (2018) 'Controlled Antenatal Thyroid Screening II: Effect of Treating Maternal Suboptimal Thyroid Function on Child Cognition', The Journal of Clinical Endocrinology & Metabolism, 103 (4):1583. | en |
dc.identifier.issn | 0021972X | |
dc.identifier.doi | 10.1210/jc.2017-02378 | |
dc.identifier.uri | http://hdl.handle.net/10545/622840 | |
dc.description.abstract | Context and Objective The Controlled Antenatal Thyroid Screening (CATS) study investigated treatment of suboptimal gestational thyroid function (SGTF) on childhood cognition and found no difference in intelligence quotient (IQ) at 3 years between children of treated and untreated SGTF mothers. We have measured IQ in the same children at age 9.5 years and included children from normal gestational thyroid function (normal-GTF) mothers. Design, Setting, and Participants One examiner, blinded to participant group, assessed children’s IQ (Wechsler Intelligence Scale for Children, Fourth Edition UK), long-term memory, and motor function (Developmental Neuropsychological Assessment II) from children of 119 treated and 98 untreated SGTF mothers plus children of 232 mothers with normal-GTF. Logistic regression explored the odds and percentages of an IQ < 85 in the groups. Results There was no difference in IQ < 85 between children of mothers with normal-GTF and combined SGTF, i.e., treated and untreated (fully adjusted odds ratio [OR] = 1.15 [95% confidence interval (CI) 0.52, 2.51]; P = 0.731). Furthermore, there was no significant effect of treatment [untreated OR = 1.33 (95% CI 0.53, 3.34); treated OR = 0.75 (95% CI 0.27, 2.06) P = 0.576]. IQ < 85 was 6.03% in normal-GTF, 7.56% in treated, and 11.22% in untreated groups. Analyses accounting for treated-SGTF women with free thyroxine > 97.5th percentile of the entire CATS-I cohort revealed no significant effect on a child’s IQ < 85 in CATS-II. IQ at age 3 predicted IQ at age 9.5 (P < 0.0001) and accounted for 45% of the variation. Conclusions Maternal thyroxine during pregnancy did not improve child cognition at age 9.5 years. Our findings confirmed CATS-I and suggest that the lack of treatment effect may be a result of the similar proportion of IQ < 85 in children of women with normal-GTF and SGTF. | |
dc.description.sponsorship | N/A | en |
dc.language.iso | en | en |
dc.publisher | Oxford Academic | en |
dc.relation.url | https://academic.oup.com/jcem/article/103/4/1583/4802113 | en |
dc.relation.url | https://orca-mwe.cf.ac.uk/109041/1/Binder1.pdf | |
dc.rights | Archived with thanks to The Journal of Clinical Endocrinology & Metabolism | en |
dc.subject | Thyroid | en |
dc.subject | Children | en |
dc.title | Controlled antenatal thyroid screening II: Effect of treating maternal suboptimal thyroid function on child cognition. | en |
dc.type | Article | en |
dc.identifier.eissn | 19457197 | |
dc.contributor.department | Cardiff University | en |
dc.identifier.journal | The Journal of Clinical Endocrinology & Metabolism | en |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | Centre for Trials Research, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | St David’s Hospital, Cardiff and Vale University Health Board, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | Centre for Trials Research, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, Wales, United Kingdom | |
dc.contributor.institution | School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom | |
html.description.abstract | Context and Objective The Controlled Antenatal Thyroid Screening (CATS) study investigated treatment of suboptimal gestational thyroid function (SGTF) on childhood cognition and found no difference in intelligence quotient (IQ) at 3 years between children of treated and untreated SGTF mothers. We have measured IQ in the same children at age 9.5 years and included children from normal gestational thyroid function (normal-GTF) mothers. Design, Setting, and Participants One examiner, blinded to participant group, assessed children’s IQ (Wechsler Intelligence Scale for Children, Fourth Edition UK), long-term memory, and motor function (Developmental Neuropsychological Assessment II) from children of 119 treated and 98 untreated SGTF mothers plus children of 232 mothers with normal-GTF. Logistic regression explored the odds and percentages of an IQ < 85 in the groups. Results There was no difference in IQ < 85 between children of mothers with normal-GTF and combined SGTF, i.e., treated and untreated (fully adjusted odds ratio [OR] = 1.15 [95% confidence interval (CI) 0.52, 2.51]; P = 0.731). Furthermore, there was no significant effect of treatment [untreated OR = 1.33 (95% CI 0.53, 3.34); treated OR = 0.75 (95% CI 0.27, 2.06) P = 0.576]. IQ < 85 was 6.03% in normal-GTF, 7.56% in treated, and 11.22% in untreated groups. Analyses accounting for treated-SGTF women with free thyroxine > 97.5th percentile of the entire CATS-I cohort revealed no significant effect on a child’s IQ < 85 in CATS-II. IQ at age 3 predicted IQ at age 9.5 (P < 0.0001) and accounted for 45% of the variation. Conclusions Maternal thyroxine during pregnancy did not improve child cognition at age 9.5 years. Our findings confirmed CATS-I and suggest that the lack of treatment effect may be a result of the similar proportion of IQ < 85 in children of women with normal-GTF and SGTF. |