Show simple item record

dc.contributor.authorLerebours, Adélaïde
dc.contributor.authorChapman, Emma C.
dc.contributor.authorSweet, Michael J.
dc.contributor.authorHeupel, Michelle R.
dc.contributor.authorRotchell, Jeanette M.
dc.date.accessioned2018-02-19T09:43:11Z
dc.date.available2018-02-19T09:43:11Z
dc.date.issued2016-07-28
dc.identifier.citationLerebours, A. et al (2016) 'Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus', Marine Environmental Research, 120:130.en
dc.identifier.issn01411136
dc.identifier.doi10.1016/j.marenvres.2016.07.009
dc.identifier.urihttp://hdl.handle.net/10545/622164
dc.description.abstractA high prevalence of skin pigmented lesions of 15% was recently reported in coral trout Plectropomus leopardus, a commercially important marine fish, inhabiting the Great Barrier Reef. Herein, fish were sampled at two offshore sites, characterised by high and low lesion prevalence. A transcriptomic approach using the suppressive subtractive hybridisation (SSH) method was used to analyse the differentially expressed genes between lesion and normal skin samples. Transcriptional changes of 14 genes were observed in lesion samples relative to normal skin samples. These targeted genes encoded for specific proteins which are involved in general cell function but also in different stages disrupted during the tumourigenesis process of other organisms, such as cell cycling, cell proliferation, skeletal organisation and cell migration. The results highlight transcripts that are associated with the lesion occurrence, contributing to a better understanding of the molecular aetiology of this coral trout skin disease.
dc.description.sponsorshipCEFASen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0141113616301271en
dc.rightsArchived with thanks to Marine Environmental Researchen
dc.subjectFishen
dc.subjectCoral reefen
dc.subjectSkin lesionen
dc.subjectMelanosisen
dc.subjectGene expressionen
dc.titleMolecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus.en
dc.typeArticleen
dc.contributor.departmentUniversity of Hullen
dc.contributor.departmentUniversity of Derbyen
dc.contributor.departmentAustralian Institute of Marine Scienceen
dc.contributor.departmentJames Cook Universityen
dc.identifier.journalMarine Environmental Researchen
html.description.abstractA high prevalence of skin pigmented lesions of 15% was recently reported in coral trout Plectropomus leopardus, a commercially important marine fish, inhabiting the Great Barrier Reef. Herein, fish were sampled at two offshore sites, characterised by high and low lesion prevalence. A transcriptomic approach using the suppressive subtractive hybridisation (SSH) method was used to analyse the differentially expressed genes between lesion and normal skin samples. Transcriptional changes of 14 genes were observed in lesion samples relative to normal skin samples. These targeted genes encoded for specific proteins which are involved in general cell function but also in different stages disrupted during the tumourigenesis process of other organisms, such as cell cycling, cell proliferation, skeletal organisation and cell migration. The results highlight transcripts that are associated with the lesion occurrence, contributing to a better understanding of the molecular aetiology of this coral trout skin disease.


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record