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    Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder

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    Authors
    Ebert, Andreas
    Edel, Marc-Andreas
    Gilbert, Paul cc
    Brüne, Martin cc
    Affiliation
    LWL University Hospital
    Fliedner Klinik
    University of Derby
    Issue Date
    2017-09-07
    
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    Abstract
    Background/Objective The role of the neuropeptide oxytocin (OT) in Borderline Personality Disorder (BPD) is poorly understood. It is particularly unknown how early experiences with caregivers moderate the action of OT in BPD. Here, we examined the association of plasma OT levels in BPD patients with the experience of compassion and recalled parental behavior during childhood. Methods Fifty-seven BPD patients and 43 healthy controls participated in the study. OT plasma levels were analyzed by radioimmunoassay. Subjects additionally completed questionnaires focusing on fears of compassion (FOC) and recalled upbringing (“Questionnaire of Recalled Parental Rearing Behavior/Fragebogen zum erinnerten elterlichen Erziehungsverhalten,” FEE). Results BPD patients had significantly lower OT plasma levels than healthy controls and differed significantly on all FOC and FEE scales; BPD patients had higher FOC scores (indicating more aversion of being compassionate to themselves and others and receiving compassion from others). They also differed in recalled parenting. In the BPD group, scores of the FOC scale “fear of compassion from others” were significantly negatively correlated with OT levels. Moreover, recalled “emotional warmth” of their parents during childhood was positively correlated with OT plasma levels of BPD subjects. No such correlations were found in the control group. Conclusion Our results corroborate findings from previous studies reporting lower OT levels in patients with BPD. Moreover, peripheral OT seems to be linked with the tolerance of compassionate feelings and early experiences with caregivers. This is consistent with other findings that OT is an important mediator of the experience of emotional warmth from others.
    Citation
    Ebert, A. et al (2017) 'Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder', Depression and Anxiety, DOI: 10.1002/da.22683
    Publisher
    Wiley
    Journal
    Depression and Anxiety
    URI
    http://hdl.handle.net/10545/621891
    DOI
    10.1002/da.22683
    Additional Links
    http://doi.wiley.com/10.1002/da.22683
    Type
    Article
    Language
    en
    ISSN
    10914269
    ae974a485f413a2113503eed53cd6c53
    10.1002/da.22683
    Scopus Count
    Collections
    Human Sciences Research Centre

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