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    The effects of 8 weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing.

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    Authors
    Tallis, Jason
    Higgins, Matthew F.
    Seebacher, Frank
    Cox, Val M.
    Duncan, Michael J. cc
    James, Rob S. cc
    Affiliation
    Coventry University
    University of Derby
    University of Sydney
    Issue Date
    2017-08-17
    
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    Abstract
    Decreased skeletal muscle performance with increasing age is strongly associated with reduced mobility and quality of life. Increased physical activity is a widely prescribed method of reducing the detrimental effects of ageing on skeletal muscle contractility. The present study uses isometric and work loop testing protocols to uniquely investigate the effects of 8 weeks of voluntary wheel running on the contractile performance of isolated dynapenic soleus and diaphragm muscles of 38 week old CD1 mice. When compared to untrained controls, voluntary wheel running induced significant improvements in maximal isometric stress and work loop power, a reduced resistance to fatigue, but greater cumulative work during fatiguing work loop contractions in isolated muscle. These differences occurred without appreciable changes in LDH, CS, SERCA or MHC expression synonymous with this form of training in younger rodent models. Despite the given improvement in contractile performance, the average running distance significantly declined over the course of the training period, indicating that this form of training may not be sufficient to fully counteract the longer term ageing induced decline in skeletal muscle contractile performance. Although these results indicate that regular low intensity physical activity may be beneficial in offsetting the age-related decline in skeletal muscle contractility, the present findings infer that future work focusing on the maintenance of a healthy body mass with increasing age and its effects on myosin-actin cross bridge kinetics and Ca(2+) handling, is needed to clarify the mechanisms causing the improved contractile performance in trained dynapenic skeletal muscle.
    Citation
    Tallis, J. et al (2017) 'The effects of 8 weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing.' Journal of Experimental Biology, doi: 10.1242/jeb.166603.
    Publisher
    The Company of Biologists Ltd.
    Journal
    The Journal of Experimental Biology
    URI
    http://hdl.handle.net/10545/621822
    DOI
    10.1242/jeb.166603
    PubMed ID
    28819051
    Additional Links
    http://jeb.biologists.org/content/early/2017/08/16/jeb.166603
    Type
    Article
    Language
    en
    ISSN
    14779145
    ae974a485f413a2113503eed53cd6c53
    10.1242/jeb.166603
    Scopus Count
    Collections
    School of Human Sciences

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