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dc.contributor.authorRye, Kara
dc.contributor.authorMortimore, Gerri
dc.contributor.authorAustin, Andrew
dc.contributor.authorFreeman, Jan G.
dc.date.accessioned2017-03-02T14:20:09Z
dc.date.available2017-03-02T14:20:09Z
dc.date.issued2009
dc.identifier.citationRye, K. Mortimore, G. et al (2009) 'Automonic dysfunction measured by baroreflex sensitivity is markedly abnormal in stable cirrhosis despite minimal systemic haemodynamic changes', Gut, 58 (Suppl. 1) A1en
dc.identifier.issn175749
dc.identifier.urihttp://hdl.handle.net/10545/621471
dc.description.abstractBaroreceptor sensitivity (BRS) is well recognised as a composite marker of the overall integrity of the autonomic nervous system, maintaining cardiovascular status both at rest and during physiological stress. Autonomic dysfunction occurs in 43–80% of cases of cirrhosis, affecting both sympathetic and parasympathetic branches. BRS impairment occurs independently of aetiology and correlates with disease severity and the hyperdynamic circulation. BRS has been studied extensively in advanced disease, especially pre-transplantation but less so in more compensated disease. Impaired BRS is associated with a 5-fold increase in mortality, independent of cirrhosis stage, yet can be improved by drugs and liver transplantation.
dc.description.sponsorshipN/Aen
dc.language.isoenen
dc.publisherBMJ Publishing Group Ltd.en
dc.relation.urlhttp://gut.bmj.com/content/58/Suppl_1/A1en
dc.subjectLiver transplantsen
dc.subjectCirrhoticsen
dc.subjectAbnormalitiesen
dc.subjectHaemodynamic responsesen
dc.subjectBaroreceptor sensitivityen
dc.titleAutomonic dysfunction measured by baroreflex sensitivity is markedly abnormal in stable cirrhosis despite minimal systemic haemodynamic changesen
dc.typeArticleen
dc.contributor.departmentUniversity of Derbyen
dc.identifier.journalGUTen
html.description.abstractBaroreceptor sensitivity (BRS) is well recognised as a composite marker of the overall integrity of the autonomic nervous system, maintaining cardiovascular status both at rest and during physiological stress. Autonomic dysfunction occurs in 43–80% of cases of cirrhosis, affecting both sympathetic and parasympathetic branches. BRS impairment occurs independently of aetiology and correlates with disease severity and the hyperdynamic circulation. BRS has been studied extensively in advanced disease, especially pre-transplantation but less so in more compensated disease. Impaired BRS is associated with a 5-fold increase in mortality, independent of cirrhosis stage, yet can be improved by drugs and liver transplantation.


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