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    Automonic dysfunction measured by baroreflex sensitivity is markedly abnormal in stable cirrhosis despite minimal systemic haemodynamic changes

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    Authors
    Rye, Kara
    Mortimore, Gerri
    Austin, Andrew
    Freeman, Jan G.
    Affiliation
    University of Derby
    Issue Date
    2009
    
    Metadata
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    Abstract
    Baroreceptor sensitivity (BRS) is well recognised as a composite marker of the overall integrity of the autonomic nervous system, maintaining cardiovascular status both at rest and during physiological stress. Autonomic dysfunction occurs in 43–80% of cases of cirrhosis, affecting both sympathetic and parasympathetic branches. BRS impairment occurs independently of aetiology and correlates with disease severity and the hyperdynamic circulation. BRS has been studied extensively in advanced disease, especially pre-transplantation but less so in more compensated disease. Impaired BRS is associated with a 5-fold increase in mortality, independent of cirrhosis stage, yet can be improved by drugs and liver transplantation.
    Citation
    Rye, K. Mortimore, G. et al (2009) 'Automonic dysfunction measured by baroreflex sensitivity is markedly abnormal in stable cirrhosis despite minimal systemic haemodynamic changes', Gut, 58 (Suppl. 1) A1
    Publisher
    BMJ Publishing Group Ltd.
    Journal
    GUT
    URI
    http://hdl.handle.net/10545/621471
    Additional Links
    http://gut.bmj.com/content/58/Suppl_1/A1
    Type
    Article
    Language
    en
    ISSN
    175749
    Collections
    School of Nursing and Professional Practice

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