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    Non-invasive assessment and prediction of clinically significant portal hypertension

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    Authors
    Rye, Kara
    Mortimore, Gerri cc
    Austin, Andrew
    Freeman, Jan G.
    Affiliation
    Royal Derby Hospital
    Issue Date
    2011-03-13
    
    Metadata
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    Abstract
    Hepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres. Reduction of HVPG to ≥12 mm Hg or by >20% significantly reduces bleeding risk and mortality. Detection of non-responders requires repeated HVPG measurement as conventional non-invasive assessment is not accurate in predicting haemodynamic response. Cirrhotics have a hyperdynamic circulation and impaired baroreceptor sensitivity (BRS). The authors assessed whether non-invasive measurement of systemic haemodynamics and BRS detected clinically significant portal hypertension (CSPH, HVPG ≥12 mm Hg).
    Citation
    Rye K, Mortimore G, Austin A, et al (2011) 'Non-invasive assessment and prediction of clinically significant portal hypertension', Gut, 60:A245-A246.
    Publisher
    BMJ Publishing Group Ltd.
    Journal
    Gut
    URI
    http://hdl.handle.net/10545/621469
    DOI
    10.1136/gut.2011.239301.521
    Additional Links
    http://gut.bmj.com/cgi/doi/10.1136/gut.2011.239301.521
    Type
    Article
    Language
    en
    ISSN
    175749
    ae974a485f413a2113503eed53cd6c53
    10.1136/gut.2011.239301.521
    Scopus Count
    Collections
    School of Nursing and Professional Practice

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