Non-invasive assessment and prediction of clinically significant portal hypertension
AffiliationRoyal Derby Hospital
MetadataShow full item record
AbstractHepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres. Reduction of HVPG to ≥12 mm Hg or by >20% significantly reduces bleeding risk and mortality. Detection of non-responders requires repeated HVPG measurement as conventional non-invasive assessment is not accurate in predicting haemodynamic response. Cirrhotics have a hyperdynamic circulation and impaired baroreceptor sensitivity (BRS). The authors assessed whether non-invasive measurement of systemic haemodynamics and BRS detected clinically significant portal hypertension (CSPH, HVPG ≥12 mm Hg).
CitationRye K, Mortimore G, Austin A, et al (2011) 'Non-invasive assessment and prediction of clinically significant portal hypertension', Gut, 60:A245-A246.
PublisherBMJ Publishing Group Ltd.