Non-invasive assessment and prediction of clinically significant portal hypertension
Abstract
Hepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres. Reduction of HVPG to ≥12 mm Hg or by >20% significantly reduces bleeding risk and mortality. Detection of non-responders requires repeated HVPG measurement as conventional non-invasive assessment is not accurate in predicting haemodynamic response. Cirrhotics have a hyperdynamic circulation and impaired baroreceptor sensitivity (BRS). The authors assessed whether non-invasive measurement of systemic haemodynamics and BRS detected clinically significant portal hypertension (CSPH, HVPG ≥12 mm Hg).Citation
Rye K, Mortimore G, Austin A, et al (2011) 'Non-invasive assessment and prediction of clinically significant portal hypertension', Gut, 60:A245-A246.Publisher
BMJ Publishing Group Ltd.Journal
GutDOI
10.1136/gut.2011.239301.521Additional Links
http://gut.bmj.com/cgi/doi/10.1136/gut.2011.239301.521Type
ArticleLanguage
enISSN
175749ae974a485f413a2113503eed53cd6c53
10.1136/gut.2011.239301.521