Browsing Research and Knowledge Exchange by Authors
Homo‐ and heteroleptic phototoxic dinuclear metallo‐intercalators based on Ru II(dppn) intercalating moieties: synthesis, optical and biological studies.Saeed, Hiwa K.; Jarman, Paul J.; Archer, Stuart; Sreedharan, Sreejesh; Saeed, Ibrahim Q.; Mckenzie, Luke K.; Weinstein, Julia A.; Buurma, Niklaas J.; Smythe, Carl G. W.; Thomas, Jim A.; et al. (Wiley, 2017-09-27)Using a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light‐switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.