• Login
    View Item 
    •   Home
    • Research Publications
    • Health & Social Care
    • School of Nursing and Professional Practice
    • View Item
    •   Home
    • Research Publications
    • Health & Social Care
    • School of Nursing and Professional Practice
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UDORACommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About and further information

    AboutOpen Access WebpagesOpen Access PolicyTake Down Policy University Privacy NoticeUniversity NewsTools for ResearchersLibraryUDo

    Statistics

    Display statistics

    Evaluation of the efficacy and safety of single dose iron infusion in clinical practice

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Grant, Claire
    Scott, Robert
    Mortimore, Gerri cc
    Austin, Andrew
    Affiliation
    University of Derby
    Issue Date
    2013-06-08
    
    Metadata
    Show full item record
    Abstract
    Introduction Total dose iron (TDI) infusion therapy has been utilised for several years in our hospital but has previously necessitated multiple admissions or an overnight stay. Shorter duration agents have been introduced to try to alleviate this significant cost burden. Aims/Background Having recently introduced a short duration TDI infusion (Monofer©) as first-line parental iron therapy in our hospital, we undertook an audit to examine its efficacy and safety. Method We audited the notes of those who had received short duration TDI since its introduction. TDI doses had been calculated by an experienced pharmacist from baseline haemoglobin (Hb), ideal body weight and target Hb according to SPC guidance. Results Efficacy Data 40 consecutive patients received a TDI between May 2012 and January 2013. Pre-infusion Hb was 9.50 [8.75–10.1] (median [IQR]). For the 25 patients who had an Hb taken at 3–5 weeks post infusion, Hb was 11.6 [10.6–12.1], significantly higher than prior to infusion (p<0.001), with an increment of 1.8 [1.35–2.70].⇓ Figure 1 Figure 1 Safety Data Of the 40 patients who received Monofer, 4 had adverse reactions within 5 minutes of commencement which led to discontinuation of the infusion (10%). 3 patients experienced an allergic-type reaction with facial swelling and dyspnoea. 1 patient experienced profuse vomiting and diarrhoea. No delayed reactions were observed. Conclusion Utilisation of Monofer in our clinical practice has shown a sub-optimal attainment of Hb target. Furthermore, the frequency of adverse reactions was much higher than expected from those reported in the product SPC or previous studies in renal patients. In light of these observations, we no longer use Monofer®.
    Citation
    Grant, C. et al (2013) 'Evaluation of the efficacy and safety of single dose iron infusion in clinical practice', Gut, 62 (Suppl 2):A30.2.
    Publisher
    BMJ Publishing Group Ltd.
    Journal
    Gut
    URI
    http://hdl.handle.net/10545/621401
    DOI
    10.1136/gutjnl-2013-305143.72
    Additional Links
    http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2013-305143.72
    Type
    Meetings and Proceedings
    Language
    en
    ISSN
    175749
    EISSN
    14683288
    ae974a485f413a2113503eed53cd6c53
    10.1136/gutjnl-2013-305143.72
    Scopus Count
    Collections
    School of Nursing and Professional Practice

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.