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    Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels

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    Authors
    Lu, Yiling
    Michel, C. C.
    Wang, Wen
    Affiliation
    University of Derby
    Issue Date
    2012-05
    
    Metadata
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    Abstract
    To elucidate the clearance of dissolved inert gas from tissues, we have developed numerical models of gas transport in a cylindrical block of tissue supplied by one or two capillaries. With two capillaries, attention is given to the effects of co-current and counter-current flow on tissue gas clearance. Clearance by counter-current flow is compared with clearance by a single capillary or by two co-currently arranged capillaries. Effects of the blood velocity, solubility, and diffusivity of the gas in the tissue are investigated using parameters with physiological values. It is found that under the conditions investigated, almost identical clearances are achieved by a single capillary as by a co-current pair when the total flow per tissue volume in each unit is the same (i.e., flow velocity in the single capillary is twice that in each co-current vessel). For both co-current and counter-current arrangements, approximate linear relations exist between the tissue gas clearance rate and tissue blood perfusion rate. However, the counter-current arrangement of capillaries results in less-efficient clearance of the inert gas from tissues. Furthermore, this difference in efficiency increases at higher blood flow rates. At a given blood flow, the simple conduction-capacitance model, which has been used to estimate tissue blood perfusion rate from inert gas clearance, underestimates gas clearance rates predicted by the numerical models for single vessel or for two vessels with co-current flow. This difference is accounted for in discussion, which also considers the choice of parameters and possible effects of microvascular architecture on the interpretation of tissue inert gas clearance.
    Citation
    Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels 2012, 113 (3):487 Journal of Applied Physiology
    Journal
    Journal of Applied Physiology
    URI
    http://hdl.handle.net/10545/313833
    DOI
    10.1152/japplphysiol.00006.2012
    Additional Links
    http://jap.physiology.org/cgi/doi/10.1152/japplphysiol.00006.2012
    Type
    Article
    Language
    en
    ISSN
    8750-7587
    1522-1601
    ae974a485f413a2113503eed53cd6c53
    10.1152/japplphysiol.00006.2012
    Scopus Count
    Collections
    Department of Mechanical Engineering & the Built Environment

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