• Effect of exercise interventions on perceived fatigue in people with multiple sclerosis: synthesis of meta-analytic reviews

      Safari, Reza; Van der Linden, Marietta L.; Mercer, Tom H.; University of Derby; Queen Margaret University; Centre for Health & Social Care Research, College of Health & Social Care, University of Derby, Derby, DE22 1GB, UK; Centre for Health & Social Care Research, College of Health & Social Care, University of Derby, Derby, DE22 1GB, UK; Centre for Health & Social Care Research, College of Health & Social Care, University of Derby, Derby, DE22 1GB, UK (Future Medicine, 2017-06-20)
      Although exercise training has been advocated as a nonpharmacological treatment for multiple sclerosis (MS) related fatigue, no consensus exists regarding its effectiveness. To address this, we collated meta-analytic reviews that explored the effectiveness of exercise training for the treatment of MS-related fatigue. We searched five online databases for relevant reviews, published since 2005, and identified 172 records. Five reviews were retained for systematic extraction of information and evidence quality analysis. Although our review synthesis indicated that exercise training interventions have a moderate effect on fatigue reduction in people with MS, no clear insight was obtained regarding the relative effectiveness of specific types or modes of exercise intervention. Moreover, Grading of Recommendation Assessment, Development and Evaluation revealed that the overall quality of evidence emanating from these five reviews was ‘very low’.
    • Fatigue interventions in long term, physical health conditions: a scoping review of systematic reviews.

      Hulme, Katrin; Safari, Reza; Thomas, Sarah; Mercer, Tom; White, Claire; Van der Linden, Marietta; Moss-Morris, Rona; University of Derby; King’s College London; Staffordshire University; et al. (PLOS, 2018-10-12)
      Fatigue is prominent across many long term physical health conditions. This scoping review aimed to map the fatigue intervention literature, to ascertain if certain interventions may be effective across conditions, and if novel interventions tested in specific long term conditions may be promising for other conditions.