• Children's construction task performance and spatial ability: controlling task complexity and predicting mathematics performance.

      Richardson, Miles; Hunt, Thomas E.; Richardson, Cassandra; University of Derby (2014-12)
      This paper presents a methodology to control construction task complexity and examined the relationships between construction performance and spatial and mathematical abilities in children. The study included three groups of children (N = 96); ages 7-8, 10-11, and 13-14 years. Each group constructed seven pre-specified objects. The study replicated and extended previous findings that indicated that the extent of component symmetry and variety, and the number of components for each object and available for selection, significantly predicted construction task difficulty. Results showed that this methodology is a valid and reliable technique for assessing and predicting construction play task difficulty. Furthermore, construction play performance predicted mathematical attainment independently of spatial ability.
    • The Eag potassium channel as a new prognostic marker in ovarian cancer.

      Asher, Viren; Khan, Raheela; Warren, Averil; Shaw, Robert; Schalkwyk, Gerhard V.; Bali, Anish; Sowter, Heidi M.; Royal Derby Hospital, School of Graduate Entry Medicine and Health, Department of Obstetrics and Gynaecology; University of Derby (2010)
      Ovarian cancer is the second most common cancer of the female genital tract in the United Kingdom (UK), accounting for 6% of female deaths due to cancer. This cancer is associated with poor survival and there is a need for new treatments in addition to existing chemotherapy to improve survival. Potassium (K+) channels have been shown to be overexpressed in various cancers where they appear to play a role in cell proliferation and progression.
    • Identifying the task variables that predict object assembly difficulty.

      Richardson, Miles; Jones, Gary; Torrance, Mark; University of Derby (2006)
      We investigated the physical attributes of an object that influence the difficulty of its assembly. Identifying attributes that contribute to assembly difficulty will provide a method for predicting assembly complexity.
    • Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.

      Dafou, Dimitra; Grun, Barbara; Sinclair, Jonathan; Lawrenson, Kate; Benjamin, Elizabeth C.; Hogdall, Estrid; Kruger-Kjaer, Susanne; Christensen, Lise; Sowter, Heidi M.; Al-Attar, Ahmed; et al. (2010-07)
      We used a functional complementation approach to identify tumor-suppressor genes and putative therapeutic targets for ovarian cancer. Microcell-mediated transfer of chromosome 18 in the ovarian cancer cell line TOV21G induced in vitro and in vivo neoplastic suppression. Gene expression microarray profiling in TOV21G(+18) hybrids identified 14 candidate genes on chromosome 18 that were significantly overexpressed and therefore associated with neoplastic suppression. Further analysis of messenger RNA and protein expression for these genes in additional ovarian cancer cell lines indicated that EPB41L3 (erythrocyte membrane protein band 4.1-like 3, alternative names DAL-1 and 4.1B) was a candidate ovarian cancer-suppressor gene. Immunoblot analysis showed that EPB41L3 was activated in TOV21G(+18) hybrids, expressed in normal ovarian epithelial cell lines, but was absent in 15 (78%) of 19 ovarian cancer cell lines. Using immunohistochemistry, 66% of 794 invasive ovarian tumors showed no EPB41L3 expression compared with only 24% of benign ovarian tumors and 0% of normal ovarian epithelial tissues. EPB41L3 was extensively methylated in ovarian cancer cell lines and primary ovarian tumors compared with normal tissues (P = .00004), suggesting this may be the mechanism of gene inactivation in ovarian cancers. Constitutive reexpression of EPB41L3 in a three-dimensional multicellular spheroid model of ovarian cancer caused significant growth suppression and induced apoptosis. Transmission and scanning electron microscopy demonstrated many similarities between EPB41L3-expressing cells and chromosome 18 donor-recipient hybrids, suggesting that EPB41L3 is the gene responsible for neoplastic suppression after chromosome 18 transfer. Finally, an inducible model of EPB41L3 expression in three-dimensional spheroids confirmed that reexpression of EPB41L3 induces extensive apoptotic cell death in ovarian cancers.
    • Perceived maternal parenting self-efficacy (PMP S-E) tool: development and validation with mothers of hospitalized preterm neonates.

      Barnes, Christopher; Adamson-Macedo, Elvidina N.; University of Wolverhampton, Division of Psychology. (2007-12)
      This paper is a report of a study to develop and test the psychometric properties of the Perceived Maternal Parenting Self-Efficacy tool.