• ‘All the burden on all the carers’: exploring quality of life with family caregivers of Huntington’s disease patients

      Aubeeluck, Aimee; Buchanan, Heather; Stupple, Edward J. N.; University of Derby (2011-11-13)
    • Further evidence of reliability and validity of the Huntington’s disease quality of life battery for carers: Italian and French translations

      Aubeeluck, Aimee; Dorey, Julie; Squitieri, Ferdinando; Clay, Emilie; Stupple, Edward J. N.; De Nicola, Annunziata; Buchanan, Heather; Martino, Tiziana; Toumi, Mondher; University of Derby (2012-07-21)
      Background Existing research suggests that family caregivers of persons with Huntington’s disease (HD) face a distinct series of problems, linked to the complex nature of the disease. Aubeeluck and Buchanan (Clin Genet, 71(5):434–445, 2007) developed and validated a disease-specific measure used to explore caregivers quality of life and assess the efficacy of therapeutic interventions. This current study builds on this research through the validation of French and Italian translations of the Huntington’s disease quality of life battery for carers (HDQoL-C). Method A total of 301 family carers completed the HDQoL-C. Participants were recruited through the “Euro-HDB” study which is measuring the burden in HD across Europe and the USA. Results Factor analysis demonstrated good internal consistency, reliability and congruent validity. Carers who cared for patients with less clinically severe symptoms reported significantly better QoL than carers of patients with more clinically severe symptoms. Discussion Findings indicate the HDQoL-C is multi-lingual, multi-cultural and easily applicable in other languages.
    • Impact of chronic somatoform and osteoarthritis pain on conscious and preconscious cognitive processing

      Dohrenbusch, Ralf; Buchanan, Heather; Lipka, Sigrid; Ott, Ralf (2013-06-21)
      The study investigates the impact of chronic pain (CP) on conscious and preconscious cognitive processes and on guessing behavior, and examines the mediating effect of a depressive state. Twenty-eight patients with CP due to hip osteoarthritis, 32 patients with a somatoform disorder including pain symptoms, and 31 participants who did not have CP were examined within the framework of a modified Process-Dissociation-Procedure. Neutral, health threatening and general threatening stimuli were presented acoustically in a lexical decision task. Parameters of conscious processing, preconscious processing, and of chance were estimated by a multinomial modelling procedure. CP-patients with osteoarthritis showed the lowest level of conscious processing and the highest level of guessing behavior. Patients with somatoform pain tended to react preconsciously to health threatening stimuli but overall showed a profile similar to that of controls who did not have CP. The impact of the threatening quality of stimuli on different levels of cognitive processing was weak. Depression did not mediate between the experience of pain and estimates of conscious and preconscious processing. Perspective: The impact of CP on preconscious and conscious cognitive processing depends on types and causes of pain. The experience of CP caused by inflammation or physical damage tends to reduce the probability of conscious processing and to provoke memory biases. CP in the context of a somatoform disorder seems to have less impact on cognitive functions.