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The Eag potassium channel as a new prognostic marker in ovarian cancer.Asher, Viren; Khan, Raheela; Warren, Averil; Shaw, Robert; Schalkwyk, Gerhard V.; Bali, Anish; Sowter, Heidi M.; Royal Derby Hospital, School of Graduate Entry Medicine and Health, Department of Obstetrics and Gynaecology; University of Derby (2010)Ovarian cancer is the second most common cancer of the female genital tract in the United Kingdom (UK), accounting for 6% of female deaths due to cancer. This cancer is associated with poor survival and there is a need for new treatments in addition to existing chemotherapy to improve survival. Potassium (K+) channels have been shown to be overexpressed in various cancers where they appear to play a role in cell proliferation and progression.
The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line.Asher, Viren; Warren, Averil; Shaw, Robert; Sowter, Heidi M.; Bali, Anish; Khan, Raheela; Royal Derby Hospital, School of Graduate Entry Medicine and Health; University of Derby, Faculty of Education, Health and Science (2011-03)The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by which Eag and HERG channels affect cell proliferation in ovarian cancer cells is required and therefore we investigated their role in cell proliferation and their effect on the cell cycle and apoptosis of ovarian cancer cells.