• I am here to learn biology, not 'personal development': testing the blueprint for Careers

      Neary, Siobhan; Beizsley, Celia; University of Derby, iCeGS; University of Derby, Career Development Centre (2012-10-09)
      University careers services in the UK are increasingly challenged to contribute to ensuring graduates find, obtain and engage with graduate level opportunities. Parallel to this the range of graduate opportunities has become increasingly competitive. All universities strive to identify and promote their added value to the academic experience. The Blueprint for Careers (LSIS, 2011a) builds on international practice in developing career management competencies. It offers a useful framework, which can be used by careers professionals to work with students and academics to review and assess the attainment of career competencies. This multi-layered research project utilised an on-line questionnaire, student peer researcher training and focus groups to engage a sample of students across all faculties of the university. The indicative findings present a mixed picture, with students generally feeling most confident about their attitudes to lifelong learning, and how changes in society impact on life, learning and work. Areas of least confidence focused on the ability to make effective career and life decisions and planning and managing life, learning and work. In relation to programme provision students welcomed opportunities to engage in extra curricular activities but demanded more focused and relevant work experience opportunities.
    • I am really ever so not good at graph drawing: the Charlie and Lola approach to lineweaver-burk plots

      Beaumont, Ellen S.; Wilkinson, Alan-Shaun; Derby University (The Chemical Educator, 2015-09)
      Marking exam scripts can be eye-opening to instructors in terms of identifying errors in their preconceptions of students’ data handling and graph drawing skills. This short communication reports a novel approach to reducing the errors of undergraduate Biological and Forensic Science students in graphical representation of enzyme kinetic data. The approach involves using fictional units, the names of which are drawn from a popular children’s animated television series. Increases of 30.8% and 25.9% were recorded in the marks awarded for correct axis labelling in an end of module exam when compared to the two previous cohorts, suggesting the approach may be worthy of further exploration.
    • 'I felt like I was doing something wrong': A qualitative exploration of mothers' experiences of breastfeeding

      Jackson, Jessica; Hallam, Jenny; University of Derby (MAG, 2019-04-18)
      Despite its multiple health benefits, rates of breastfeeding to 2 years and beyond remain low in the UK. This qualitative study explored the experiences of support provided by health professionals to mothers breastfeeding beyond infancy. A key finding of the study was that health services are effective at supporting breastfeeding in the postnatal period, but that beyond the 1-year review the focus shifts to rapid weaning. A new approach to support breastfeeding continuation alongside the introduction of complementary foods is needed in line with professional guidance and recommendations. As critical reflective practitioners, health visitors are ideally placed to support and educate women about the wider social complexities of breastfeeding. However, health service commissioners need to recognise the importance of investment in the profession to enable health visitors to use their skills fully.
    • “I smoked them out”: Perspectives on the emergence of folk opera or ‘musical plays’ in Uganda.

      Kasule, Sam; University of Derby (Boydell and Brewer, 2020-11-20)
      Music is often cited as a central artistic mode in African theatre and performance practices. However, little attention has been paid to music theatre on the continent in general, and to opera in particular, with the exceptions of a few noted genres, such as Concert Party or the Yoruba "folk opera" of the 1960s, and the emerging research on opera culture in South Africa. This volume of African Theatre highlights the diversity across the continent from a variety of perspectives - including those of genre, media, and historiography. Above all, it raises questions and encourages debate: What does "opera" mean in African and African diasporic contexts? What are its practices and legacies - colonial, postcolonial and decolonial; what is its relation to the intersectionalities of race and class? How do opera and music theatre reflect, change or obscure social, political and economic realities? How are they connected to educational and cultural institutions, and non-profit organisations? And why is opera contradictorily, at various times, perceived as both "grand" and "elitist, "folk" and "quotidian", "Eurocentric" and "indigenous"? Contributors also address aesthetic transformation processes, the porousness of genre boundaries and the role of space and place, with examples ranging from Egypt to South Africa, from Uganda to West Africa and the USA. The playscript in this volume is We Take Care of Our Own by Zainabu Jallo GUEST EDITORS: Christine Matzke, Lena van der Hoven, Christopher Odhiambo & Hilde Roos Series Editors: Yvette Hutchison, Reader, Department of Theatre & Performance Studies, University of Warwick; Chukwuma Okoye, Reader in African Theatre & Performance University of Ibadan; Jane Plastow, Professor of African Theatre, University of Leeds.
    • 'I Speak about Myself to You' – Renegotiating the Voice of Documentary through Animation Aesthetics

      Bosward, Marc; Bevan, Greg; University of Derby; University of Salford (The Higher Education Academy, 23/06/2011)
      Documentary practice has long been encumbered with journalistic and pseudo-scientific expectations; the gathering of evidence, the balancing of material and the objective presentation of accurate and informative data. Overwhelmingly, documentary audiences are encouraged to believe in an objective reality and, by extension, to anticipate fidelity to it. Filmmakers' aesthetic choices are selected and organised to persuade the viewer that the resulting voice of the documentary is an honest, rational and sensible point of view. This paper will explore the documentary filmmaker's detachment from an obligation to deliver objective truth by applying the visual, aural and temporal distortions of animation to interrogate conventional notions of knowledge, reliability and authority. By taking a collaborative approach to the research project, the paper will explore the inherent transformative, non-representational and illusory nature of animation in relation to the construction of authorial voice for documentary. Drawing on the theory and practice of filmmakers Aleksandr Sokurov and Alexander Kluge, the paper will assess to what extent truth can be derived from expressionistic aesthetic components as readily as they can from the narration of factual information and photographic reality; can animation in documentary assimilate fiction into fact and synthesise truth and fantasy? Further, the paper will argue that the didactic voice of traditional, expository documentary encourages passive observation while animation can provoke a more poetic interpretation of the films' diegesis; how can the authenticity of documentary material be legitimised by foregrounding authorial mediation rather than attempting to camouflage subjectivity? The introduction of animation aesthetics into documentary realism offers the filmmaker a wider choice of expressive tools to define, extend and affirm their own personal voice. This paper will offer a practical assessment of these issues, offering new approaches for filmmakers to explore the epistemological resonance of their craft, and to extend the formal and thematic parameters that determine documentary's status as nonfiction testimony.
    • “I think I’ll just go and eat worms”: the effect of bullying on self-esteem,. Body image, and eating disordered behaviour

      Blake, C. E.; Haynes, Caroline Anne; University of Derby (British Psychological Society, 1999)
      The link between low self-esteem and eating disorders; and body image and eating disorders, has been well established. In addition, Button, Sonuga-Barke, Davies and Thompson, (1996) suggested that problems at school may also contribute to the development of eating disorders. In the present study the effects of bully on self-esteem , body image and eating disordered behaviour were investigate in a cohort of fifty eight college students aged between sixteen and twenty. Participants completed questionnaire measures of social and global self-esteem, body image distortion, bullying and prevalence of anorexia nervosa and bulimia nervosa. Analysis revealed a significant effect for bullying on self-esteem and body image when controlling for gender, and on eating disordered behaviour in females but not in males (P<.01). Individuals who were bulletined had significantly lower self-esteem and significantly higher body image distortion and eating disordered scores than individual who were not bullied. The study highlights the importance of bullying as a possible aetiological factor in the developing of eating disordered behaviour.
    • I want you to participate: Pause for thought

      Penna, Xristina; University of Leeds (University of Leeds, 31/05/2017)
      This colloquium took place at Stage@leeds, School of Performance and Cultural Industries, University of Leeds on May 31st 2017. It aimed to contribute to Harpin and Nicholson’s ‘reflective response to why the contemporary moment appears somehow to need participation’ (2017: 15). It focused on questions regarding the resistances, crises, or ethical dilemmas encountered by the invited artists, and creative researchers when using participatory formats. Aim was to collect direct insights from an eclectic group of artists, and creative researchers who work across installation, intermedia, immersive, applied art, and performance, and who utilise these formats.
    • "I'm 100% for it! I'm a convert!": Women's experiences of a yoga programme during treatment for gynaecological cancer; an interpretative phenomenological analysis.

      Archer, Stephanie; Phillips, Elly; Montague, Jane; Bali, Anish; Sowter, Heidi M.; University of Derby; Royal Derby Hospital, Derby (Elsevier, 2015-02)
      To explore patients' experiences of taking part in a yoga intervention while undergoing treatment for gynaecological cancer.
    • I'm lucky. I love my job

      Moore, Nicki; University of Derby (Evropská Kontakní Skupina (EKS), 2017-06)
      This chapter argues for the need for Careers Advisers to focus on clients happiness as an outcome of their practice.
    • 'I'm not X, I just want Y': formulating 'wants' in interaction

      Childs, Carrie; Loughborough University (2012-04-30)
      This article provides a conversation analytic description of a two-part structure, ‘I don’t want X, I want/just want Y’. Drawing on a corpus of recordings of family mealtimes and television documentary data, I show how speakers use the structure in two recurrent environments. First, speakers may use the structure to reject a proposal regarding their actions made by an interlocutor. Second, speakers may deliver the structure following a co-interactant’s formulation of their actions or motivations. Both uses decrease the likelihood of challenge in third-turn position. When responding to multi-unit turns speakers routinely deal with the last item first. The value of ‘I want Y’ is to formulate an alternative sense of agency which undermines the preceding turn and shifts the trajectory of the ongoing sequence. The article contributes to work in discursive psychology as I show how speakers may formulate their ‘wants’ in the service of sequentially unfolding social interaction.
    • Icarus

      Marshall, Alice; University of Derby (2016-09)
      Live Dance performance, shown here in video form: Inspired by the well known Greek myth of Icarus; the boy who flew too close to the sun – Artistic Director and Choreographer, Alice Vale is collaborating with Rob and Matt Vale of digital art company, Illuminos, to bring the tale to life. Icarus is the son of Daedalus, an inventor who is involuntarily creating a maze at the hands of King Minos. The performance explores themes of over ambition, ignorance and recklessness whilst conveying the intimate relationship between father and son. A consistent multi-media of light, sound, animation and contemporary dance brings the piece an additional dimension, of which heightens the depth of the tale. The digital animations interact with and respond to the choreography, of which captures and transforms imagination into reality, allowing the performance to thrive and come to life. All is revealed in the final scene, a moment of soaring, with entirety and ambition. No fear, doubtless and reaching for your desires. “Never regret thy fall.”
    • Icarus, grannies, black holes and the death of privacy: exploring the use of digital networks for career enactment

      Staunton, Tom; University of Derby (Taylor and Francis, 2019-11-28)
      New perspectives on how digital networks can be understood as an environment for career enactment are explored in this article, in particular, through using critical perspectives on technology, especially in the context of prevailing instrumental perspectives in the majority of the career development literature. Thus, the narratives of people using digital networks for their careers were explored using an Interpretative Phenomenological Analysis. The results are captured in three main themes or critical discourses: the speed and scale of digital environments, game-like features of social media interactions and a divide between offline and online worlds. These are presented as sites for critical investigation and are aligned with technological and socio-cultural critical theories.
    • Icarus: Project reports and education pack.

      Marshall, Alice; University of Derby (Adair to Dance, 2015)
    • The idea of legal convergence and international economic law

      Platsas, Antonios E.; International Institute for the Sociology of Law, Oñati, Spain; University of Derby (Inderscience Publishers, 2009)
      The convergence of different legal systems is one of the leading theses in the discipline of law. This paper proposes that international economic law is one of the great sources of inspiration for the coming together of various legal systems around the world. The paper will explore the European Union experience in this respect and it will analyse a number of legal principles which promote the idea of legal convergence in the sphere of international economic law. Furthermore, referral will be made to the organisations promoting the convergence of legal systems such as the International Monetary Fund (IMF), the World Bank Group (WB) and the World Trade Organization (WTO).
    • Identification and characterisation of NANOG+/ OCT-4<sup>high</sup>/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines

      Balahmar, Reham M.; Boocock, David J.; Coveney, Clare; Ray, Sankalita; Vadakekolathu, Jayakumar; Regad, Tarik; Ali, Selman; Sivasubramaniam, Shiva; Nottingham Trent University (Impact Journals, 2018-01-11)
      Treatment of gestational trophoblastic diseases (GTD) involves surgery, radiotherapy and chemotherapy. Although, these therapeutic approaches are highly successful, drug resistance and toxicity remain a concern for high risk patients. This Chemoresistance has also been observed in the presence of cancer stem cells that are thought to be responsible for cases of cancer recurrence. In this study, we report the presence of previously unknown populations of trophoblastic stem-like cells (SLCs) that are resistant to the chemotherapeutic drug doxorubicin. We demonstrate that these populations express the stem cell markers NANOG and Sox2 and higher levels of OCT-4 (NANOG+/OCT-4high/SOX2+). Although chemoresistant, we show that the invasive capacity of these trophoblastic SLCs is significantly inhibited by doxorubicin treatment. To better characterise these populations, we also identified cellular pathways that are involved in SLCs-chemoresistance to doxorubicin. In summary, we provide evidence of the presence of NANOG+/OCT-4+/SOX2+ trophoblastic SLCs that are capable to contribute to the susceptibility to GTD and that may be involved in Chemoresistance associated with drug resistance and recurrence in high risk GTDs’ patients. We propose that targeting these populations could be therapeutically exploited for clinical benefit.
    • Identification of a bacterial pathogen associated with Porites white patch syndrome in the Western Indian Ocean

      Séré, Mathieu G.; Chabanet, Pascale; Quod, Jean-Pascal; Sweet, Michael J.; Tortosa, Pablo; Schleyer, Michael; University of Derby; Agence pour la Recherche et la Valorisation Marines (ARVAM); Ste Clotilde Reunion Island France; Unité Mixte de Recherche “Processus Infectieux en Milieu Insulaire Tropical” (UMR PIMIT); Université de La Réunion; Inserm1187; CNRS9192, IRD249; Plateforme de Recherche CYROI; 2 rue Maxime Rivière 97490 Ste Clotilde Saint Denis France; IRD - UMR ENTROPIE; Labex CORAIL; CS 41095 97495 Sainte Clotilde Cedex La Réunion; et al. (Wiley, 2015-08-24)
      Porites white patch syndrome (PWPS) is a coral disease recently described in the Western Indian Ocean. This study aimed to isolate and identify potential pathogens associated with PWPS utilizing both culture and nonculture screening techniques and inoculation trials. A total of 14 bacterial strains (those dominant in disease lesions, absent or rare in healthy tissues and considered potential pathogens in a previous study) were cultured and used to experimentally inoculate otherwise healthy individuals in an attempt to fulfil Henle–Koch's postulates. However, only one (P180R), identified as closely related (99–100% sequence identity based on 1.4 kb 16S RNA sequence) to Vibrio tubiashii, elicited signs of disease in tank experiments. Following experimental infection (which resulted in a 90% infection rate), the pathogen was also successfully re-isolated from the diseased tissues and re-inoculated in healthy corals colonies, therefore fulfilling the final stages of Henle–Koch's postulates. Finally, we report that PWPS appears to be a temperature-dependent disease, with significantly higher tissue loss (anova: d.f. = 2, F = 39.77, P < 0.01) occurring at 30 °C [1.45 ± 0.85 cm2 per day (mean ± SE)] compared to ambient temperatures of 28 and 26 °C (0.73 ± 0.80 cm2 per day (mean ± SE) and 0.51 ± 0.50 cm2 per day (mean ± SE), respectively).
    • Identification of an arginine-rich motif in human papillomavirus type 1 E1^E4 protein necessary for E4-mediated inhibition of cellular DNA Synthesis In Vitro and in Cells

      Roberts, Sally; Kingsbury, S. R.; Stoeber, K.; Knight, Gillian L.; Gallimore, P. H.; Williams, Gareth H. (2013-03-20)
      Productive infections by human papillomaviruses (HPVs) are restricted to nondividing, differentiated keratinocytes. HPV early proteins E6 and E7 deregulate cell cycle progression and activate the host cell DNA replication machinery in these cells, changes essential for virus synthesis. Productive virus replication is accompanied by abundant expression of the HPV E4 protein. Expression of HPV1 E4 in cells is known to activate cell cycle checkpoints, inhibiting G2-to-M transition of the cell cycle and also suppressing entry of cells into S phase. We report here that the HPV1 E4 protein, in the presence of a soluble form of the replicationlicensing factor (RLF) Cdc6, inhibits initiation of cellular DNA replication in a mammalian cell-free DNA replication system. Chromatin-binding studies show that E4 blocks replication initiation in vitro by preventing loading of the RLFs Mcm2 and Mcm7 onto chromatin. HPV1 E4-mediated replication inhibition in vitro and suppression of entry of HPV1 E4-expressing cells into S phase are both abrogated upon alanine replacement of arginine 45 in the full-length E4 protein (E1^E4), implying that these two HPV1 E4 functions are linked. We hypothesize that HPV1 E4 inhibits competing host cell DNA synthesis in replication-activated suprabasal keratinocytes by suppressing licensing of cellular replication origins, thus modifying the phenotype of the infected cell in favor of viral genome amplification.
    • Identification of angry faces in the attentional blink

      Maratos, Frances A.; Mogg, Karin; Bradley, Brendan P. (2008)
    • Identification of multi-style hydrothermal alteration using integrated compositional and topographic remote sensing datasets

      Ferrier, Graham; Naden, Jon; Ganas, Athanassios; Kemp, Simon; Pope, Richard J. J.; University of Hull; British Geological Survey; National Observatory of Athens; British Geological Survey; University of Derby (Multidisciplinary Digital Publishing Institute (MDPI), 2016-07-29)
      The western part of the island of Milos, Greece has undergone widespread, intense alteration associated with a range of mineralization, including seafloor Mn-Fe-Ba, sub seafloor Pb-Zn-Ag, and epithermal Au-Ag. The surrounding country rocks are a mixture of submarine and subaerial calc-alkaline volcanic rocks ranging from basaltic andesite to rhyolite in composition, but are predominantly andesites and dacites. The current surface spatial distribution of the alteration mineralogy is a function not only of the original hydrothermal, but also subsequent tectonic and erosional processes. The high relief and the excellent rock exposure provide ideal conditions to evaluate the potential of Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) satellite remote sensing data to identify and differentiate the different styles of alteration mineralisation. Laboratory spectral reflectance and calculated emittance measurements of field samples, supported by XRD analysis and field mapping, were used to support the analysis. Band ratio and spectral matching techniques were applied to the shortwave-infrared (SWIR) reflectance and thermal-infrared (TIR) emissivity imagery separately and were then integrated with topographic data. The band ratio and spectral matching approaches produced similar results in both the SWIR and TIR imagery. In the SWIR imagery, the advanced argillic, argillic and hydrous silica alteration zones were clearly identifiable, while in the TIR imagery, the silicic and advanced argillic alteration zones, along with the country rock, were differentiable. The integrated mineralogical–topographic datasets provided an enhanced understanding of the spatial and altitude distribution of the alteration zones when combined with conceptual models of their genesis, which provides a methodology for the differentiation of the multiple styles of alteration.
    • Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the Secretomes of three-dimensional genetic models of ovarian carcinogenesis.

      Lawrenson, Kate; Mhawech-Fauceglia, Paulette; Worthington, Jenny; Spindler, Tassja J.; O'Brien, Darragh; Lee, Janet M.; Spain, Georgia; Sharifian, Maryam; Wang, Guisong; Darcy, Kathleen M.; et al. (Wiley, 2014-09-09)
      Epithelial ovarian cancer is still considered the most lethal gynecological malignancy and improved early detection of ovarian cancer is crucial to improving patient prognoses. To address this need, we tested whether candidate EOC biomarkers can be identified using three-dimensional in vitro models. We quantified changes in the abundance of secreted proteins in a 3D genetic model of early-stage EOC, generated by expressing CMYC and KRAS(G12V) in TERT-immortalized normal ovarian epithelial cells. Cellular proteins were labeled in live cells using stable isotopic amino acid analogues, and secreted proteins identified and quantified using liquid chromatography-tandem mass spectrometry. 37 and 55 proteins were differentially expressed by CMYC and CMYC+KRAS(G12V) expressing cells respectively (P<0.05; >2-fold). We evaluated expression of the top candidate biomarkers in ˜210 primary EOCs: CHI3L1 and FKBP4 are both expressed by >96% of primary EOCs, and FASN and API5 are expressed by 86% and 75% of cases. High expression of CHI3L1 and FKBP4 was associated with worse patient survival (P=0.042 and P=0.002 respectively). Expression of LGALS3BP was positively associated with recurrence (P=0.0001) and suboptimal debulking (P=0.018) suggesting that these proteins may be novel prognostic biomarkers. Furthermore, within early stage tumours (I/II), high expression of API5, CHI3L1 and FASN was associated with high tumour grade (P=3x10(-4) , P=0.016, P=0.010, respectively). We show in vitro cell biology models of early-stage cancer development can be used to identify novel candidate biomarkers for disease, and report the identification of proteins that represent novel potential candidate diagnostic and prognostic biomarkers for this highly lethal disease. © 2014 Wiley Periodicals, Inc.