• Culture, capitals and graduate futures: Degrees of class.

      Burke, Ciaran; Ulster University (Routledge, 2016-08-24)
      In a time of too many graduates for too few jobs, and in a context where applicants have similar levels of educational capital, what other factors influence graduate career trajectories? Based on the life history interviews of graduates and framed through a Bourdieusian sociological lens, Culture, Capitals and Graduate Futures explores the continuing role that social class as well as cultural and social capitals have on both the aspirations and expectations towards, and the trajectories within, the graduate labour market. Framed within the current context of increasing levels of university graduates and the falling numbers of graduate positions available in the UK labour market, this book provides a critical examination of the supposedly linear and meritocratic relationship between higher education and graduate employment proposed by official discourses from government at both local and national levels. Through a critical engagement with the empirical findings, Culture, Capitals and Graduate Futures asks important questions for the effective continuation of the widening participation agenda. This timely book will be of interest to higher education professionals working within widening participation policy and higher education policy.
    • Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice.

      Oharte, FPM; Parthsarathy, Vadivel; Hogg, C; Flatt, P; Ulster University (PLoS, 2018-08-29)
      Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13. This study investigated the antidiabetic effects of chronic administration of stable long acting fatty acid modified apelin analogues, namely, (Lys8GluPAL)apelin-13 amide and pGlu(Lys8GluPAL)apelin-13 amide, in high-fat fed obese-diabetic mice. Male NIH Swiss mice (groups n = 8) were maintained either on a high-fat diet (45% fat) from 8 to 28 weeks old, or control mice were fed a normal diet (10% fat). When diet induced obesity-diabetes was established after high-fat feeding, mice were injected i.p. once daily with apelin analogues, liraglutide (25 nmol/kg) or saline (controls). Administration of (Lys8GluPAL)apelin-13 amide and pGlu(Lys8GluPAL)apelin-13 amide for 28 days significantly reduced food intake and decreased body weight. Non-fasting glucose was reduced (p<0.01 to p<0.001) and plasma insulin concentrations increased (p<0.01 to p<0.001). This was accompanied by enhanced insulin responses (p<0.01 to p<0.001) and significant reductions in glucose excursion after oral (p<0.01) or i.p. (p<0.01) glucose challenges and feeding. Apelin analogues also significantly improved HbA1c (p<0.01), enhanced insulin sensitivity (p<0.01), reduced triglycerides (p<0.001), increased HDL-cholesterol (p<0.01) and decreased LDL-cholesterol (p<0.01), compared to high-fat fed saline treated control mice. Cholesterol levels were decreased (p<0.01) by pGlu(Lys8GluPAL)apelin-13 amide and both apelin treated groups showed improved bone mineral content, reduced fat deposits and increased plasma GLP-1. Daily treatment with liraglutide mirrored many of these changes (not on bone or adipose tissue), but unlike apelin analogues increased plasma amylase. Consumption of O2, production of CO2, respiratory exchange ratio and energy expenditure were improved by apelin analogues. These results indicate that long-term treatment with acylated analogues (Lys8GluPAL)apelin-13 amide and particularly pGlu(Lys8GluPAL)apelin-13 amide resulted in similar or enhanced therapeutic responses to liraglutide in high-fat fed mice. Fatty acid derived apelin analogues represent a new and exciting development in the treatment of obesity-diabetes.