Non-invasive assessment and prediction of clinically significant portal hypertension

Hdl Handle:
http://hdl.handle.net/10545/621469
Title:
Non-invasive assessment and prediction of clinically significant portal hypertension
Authors:
Rye, Kara; Mortimore, Gerri ( 0000-0001-6890-4346 ) ; Austin, Andrew; Freeman, Jan G.
Abstract:
Hepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres. Reduction of HVPG to ≥12 mm Hg or by >20% significantly reduces bleeding risk and mortality. Detection of non-responders requires repeated HVPG measurement as conventional non-invasive assessment is not accurate in predicting haemodynamic response. Cirrhotics have a hyperdynamic circulation and impaired baroreceptor sensitivity (BRS). The authors assessed whether non-invasive measurement of systemic haemodynamics and BRS detected clinically significant portal hypertension (CSPH, HVPG ≥12 mm Hg).
Affiliation:
Royal Derby Hospital
Citation:
Rye K, Mortimore G, Austin A, et al (2011) 'Non-invasive assessment and prediction of clinically significant portal hypertension', Gut, 60:A245-A246.
Publisher:
BMJ Publishing Group Ltd.
Journal:
Gut
Issue Date:
13-Mar-2011
URI:
http://hdl.handle.net/10545/621469
DOI:
10.1136/gut.2011.239301.521
Additional Links:
http://gut.bmj.com/cgi/doi/10.1136/gut.2011.239301.521
Type:
Article
Language:
en
ISSN:
175749
Sponsors:
N/A
Appears in Collections:
School of Nursing and Professional Practice

Full metadata record

DC FieldValue Language
dc.contributor.authorRye, Karaen
dc.contributor.authorMortimore, Gerrien
dc.contributor.authorAustin, Andrewen
dc.contributor.authorFreeman, Jan G.en
dc.date.accessioned2017-03-01T14:27:28Z-
dc.date.available2017-03-01T14:27:28Z-
dc.date.issued2011-03-13-
dc.identifier.citationRye K, Mortimore G, Austin A, et al (2011) 'Non-invasive assessment and prediction of clinically significant portal hypertension', Gut, 60:A245-A246.en
dc.identifier.issn175749-
dc.identifier.doi10.1136/gut.2011.239301.521-
dc.identifier.urihttp://hdl.handle.net/10545/621469-
dc.description.abstractHepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres. Reduction of HVPG to ≥12 mm Hg or by >20% significantly reduces bleeding risk and mortality. Detection of non-responders requires repeated HVPG measurement as conventional non-invasive assessment is not accurate in predicting haemodynamic response. Cirrhotics have a hyperdynamic circulation and impaired baroreceptor sensitivity (BRS). The authors assessed whether non-invasive measurement of systemic haemodynamics and BRS detected clinically significant portal hypertension (CSPH, HVPG ≥12 mm Hg).en
dc.description.sponsorshipN/Aen
dc.language.isoenen
dc.publisherBMJ Publishing Group Ltd.en
dc.relation.urlhttp://gut.bmj.com/cgi/doi/10.1136/gut.2011.239301.521en
dc.rightsArchived with thanks to Guten
dc.subjectNon-invasive samplingen
dc.subjectCirrhoticsen
dc.subjectBaroreceptor sensitivityen
dc.subjectHaemodynamic responsesen
dc.titleNon-invasive assessment and prediction of clinically significant portal hypertensionen
dc.typeArticleen
dc.contributor.departmentRoyal Derby Hospitalen
dc.identifier.journalGuten
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