Bioavailability of iodine in the UK-Peak District environment and its human bioaccessibility: an assessment of the causes of historical goitre in this area

Hdl Handle:
http://hdl.handle.net/10545/620658
Title:
Bioavailability of iodine in the UK-Peak District environment and its human bioaccessibility: an assessment of the causes of historical goitre in this area
Authors:
Mehra, Aradhana; Saikat, Sohel Quaderi; Carter, Joy E.
Abstract:
Iodine is an essential micronutrient for human health. Its deficiency causes a number of functional and developmental abnormalities such as goitre. The limestone region of Derbyshire, UK was goitre-endemic until it declined from the 1930s and the reason for this has escaped a conclusive explanation. The present study investigates the cause(s) of goitre in the UK-Peak District area through an assessment of iodine in terms of its environmental mobility, bioavailability, uptake into the food chain and human bioaccessibility. The goitre-endemic limestone area is compared with the background millstone grit area of the UK-Peak District. The findings of this study show that 'total' environmental iodine is not linked to goitre in the limestone area, but the governing factors include iodine mobility, bioavailability and bioaccessibility. Compared with the millstone grit area, higher soil pH and calcium content of the limestone area restrict iodine mobility in this area, also soil organic carbon in the limestone area is influential in binding the iodine to the soil. Higher calcium content in the limestone area is an important factor in terms of strongly fixing the iodine to the soil. Higher iodine bioaccessibility in the millstone grit than the limestone area suggests that its oral bioaccessibility is restricted in the limestone area. Iodine taken up by plant roots is transported freely into the aerial plant parts in the millstone grit area unlike the limestone area, thus providing higher iodine into the human food chain in the millstone grit area through grazing animals unlike the goitre-prevalent limestone area.
Affiliation:
University of Derby
Citation:
Mehra A, Saikat SQ, Carter JE., (2014) 'Bioavailability of iodine in the UK-Peak District environment and its human bioaccessibility: an assessment of the causes of historical goitre in this area', Environmental Monitoring and Assessment, 186 (2):987
Publisher:
Springer
Journal:
Environmental Monitoring and Assessment
Issue Date:
Feb-2014
URI:
http://hdl.handle.net/10545/620658
DOI:
10.1007/s10661-013-3433-7
PubMed ID:
24407919
Additional Links:
http://link.springer.com/10.1007/s10661-013-3433-7
Type:
Article
Language:
en
ISSN:
0167-6369; 1573-2959
Appears in Collections:
Environmental Sustainability Research Centre

Full metadata record

DC FieldValue Language
dc.contributor.authorMehra, Aradhanaen
dc.contributor.authorSaikat, Sohel Quaderien
dc.contributor.authorCarter, Joy E.en
dc.date.accessioned2016-10-24T15:41:07Z-
dc.date.available2016-10-24T15:41:07Z-
dc.date.issued2014-02-
dc.identifier.citationMehra A, Saikat SQ, Carter JE., (2014) 'Bioavailability of iodine in the UK-Peak District environment and its human bioaccessibility: an assessment of the causes of historical goitre in this area', Environmental Monitoring and Assessment, 186 (2):987en
dc.identifier.issn0167-6369-
dc.identifier.issn1573-2959-
dc.identifier.pmid24407919-
dc.identifier.doi10.1007/s10661-013-3433-7-
dc.identifier.urihttp://hdl.handle.net/10545/620658-
dc.description.abstractIodine is an essential micronutrient for human health. Its deficiency causes a number of functional and developmental abnormalities such as goitre. The limestone region of Derbyshire, UK was goitre-endemic until it declined from the 1930s and the reason for this has escaped a conclusive explanation. The present study investigates the cause(s) of goitre in the UK-Peak District area through an assessment of iodine in terms of its environmental mobility, bioavailability, uptake into the food chain and human bioaccessibility. The goitre-endemic limestone area is compared with the background millstone grit area of the UK-Peak District. The findings of this study show that 'total' environmental iodine is not linked to goitre in the limestone area, but the governing factors include iodine mobility, bioavailability and bioaccessibility. Compared with the millstone grit area, higher soil pH and calcium content of the limestone area restrict iodine mobility in this area, also soil organic carbon in the limestone area is influential in binding the iodine to the soil. Higher calcium content in the limestone area is an important factor in terms of strongly fixing the iodine to the soil. Higher iodine bioaccessibility in the millstone grit than the limestone area suggests that its oral bioaccessibility is restricted in the limestone area. Iodine taken up by plant roots is transported freely into the aerial plant parts in the millstone grit area unlike the limestone area, thus providing higher iodine into the human food chain in the millstone grit area through grazing animals unlike the goitre-prevalent limestone area.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://link.springer.com/10.1007/s10661-013-3433-7en
dc.rightsArchived with thanks to Environmental Monitoring and Assessmenten
dc.subjectEnvironmental monitoringen
dc.subjectGoiter, endemic/epidemiologyen
dc.subjectGoiter, endemic/etiologyen
dc.subjectHumansen
dc.subjectIodine analysisen
dc.subjectMicronutrientsen
dc.titleBioavailability of iodine in the UK-Peak District environment and its human bioaccessibility: an assessment of the causes of historical goitre in this areaen
dc.typeArticleen
dc.contributor.departmentUniversity of Derbyen
dc.identifier.journalEnvironmental Monitoring and Assessmenten

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