3.50
Hdl Handle:
http://hdl.handle.net/10545/314021
Title:
Multiscale modelling of fluid and solute transport in soft tissues and microvessels
Authors:
Lu, Yiling; Wang, Wen
Abstract:
This study focuses on the movement of particles and extracellular fluid in soft tissues and microvessels. It analyzes modeling applications in biological and physiological fluids at a range of different length scales: from between a few tens to several hundred nanometers, on the endothelial glycocalyx and its effects on interactions between blood and the vessel wall; to a few micrometers, on movement of blood cells in capillaries and transcapillary exchange; to a few millimetres and centimetres, on extracellular matrix deformation and interstitial fluid movement in soft tissues. Interactions between blood cells and capillary wall are discussed when the sizes of the two are of the same order of magnitude, with the glycocalyx on the endothelial and red cell membranes being considered. Exchange of fluid, solutes, and gases by microvessels are highlighted when capillaries have counter-current arrangements. This anatomical feature exists in a number of tissues and is the key in the renal medulla on the urinary concentrating mechanism. The paper also addresses an important phenomenon on the transport of macromolecules. Concentration polarization of hyaluronan on the synovial lining of joint cavities is presented to demonstrate how the mechanism works in principle and how model predictions agree to experimental observations quantitatively.
Affiliation:
University of Derby
Citation:
MULTISCALE MODELING OF FLUID AND SOLUTE TRANSPORT IN SOFT TISSUES AND MICROVESSELS 2010, 02 (01n02):127 Journal of Multiscale Modelling
Journal:
Journal of Multiscale Modelling
Issue Date:
2010
URI:
http://hdl.handle.net/10545/314021
DOI:
10.1142/S175697371000028X
Additional Links:
http://www.worldscientific.com/doi/abs/10.1142/S175697371000028X
Type:
Article
Language:
en
ISSN:
1756-9737; 1756-9745
Appears in Collections:
Mechanical/Manufacturing Engineering & Industrial Design Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorLu, Yilingen
dc.contributor.authorWang, Wenen
dc.date.accessioned2014-03-13T13:50:42Z-
dc.date.available2014-03-13T13:50:42Z-
dc.date.issued2010-
dc.identifier.citationMULTISCALE MODELING OF FLUID AND SOLUTE TRANSPORT IN SOFT TISSUES AND MICROVESSELS 2010, 02 (01n02):127 Journal of Multiscale Modellingen
dc.identifier.issn1756-9737-
dc.identifier.issn1756-9745-
dc.identifier.doi10.1142/S175697371000028X-
dc.identifier.urihttp://hdl.handle.net/10545/314021-
dc.description.abstractThis study focuses on the movement of particles and extracellular fluid in soft tissues and microvessels. It analyzes modeling applications in biological and physiological fluids at a range of different length scales: from between a few tens to several hundred nanometers, on the endothelial glycocalyx and its effects on interactions between blood and the vessel wall; to a few micrometers, on movement of blood cells in capillaries and transcapillary exchange; to a few millimetres and centimetres, on extracellular matrix deformation and interstitial fluid movement in soft tissues. Interactions between blood cells and capillary wall are discussed when the sizes of the two are of the same order of magnitude, with the glycocalyx on the endothelial and red cell membranes being considered. Exchange of fluid, solutes, and gases by microvessels are highlighted when capillaries have counter-current arrangements. This anatomical feature exists in a number of tissues and is the key in the renal medulla on the urinary concentrating mechanism. The paper also addresses an important phenomenon on the transport of macromolecules. Concentration polarization of hyaluronan on the synovial lining of joint cavities is presented to demonstrate how the mechanism works in principle and how model predictions agree to experimental observations quantitatively.en
dc.language.isoenen
dc.relation.urlhttp://www.worldscientific.com/doi/abs/10.1142/S175697371000028Xen
dc.rightsArchived with thanks to Journal of Multiscale Modellingen
dc.subjectMicrocirculationen
dc.subjectTransport solute and macromoleculesen
dc.subjectBlood-wall interactionen
dc.subjectTranscapillary exchangeen
dc.subjectTissue oxygenationen
dc.titleMultiscale modelling of fluid and solute transport in soft tissues and microvesselsen
dc.typeArticleen
dc.contributor.departmentUniversity of Derbyen
dc.identifier.journalJournal of Multiscale Modellingen
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