Welcome to UDORA, the University of Derby Online Research Archive.
UDORA is the institutional repository of research produced by staff at the University of Derby, and an archive of our completed doctoral theses.
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Communities in DSpace
Kinetic modelling of synaptic functions in the alpha rhythm neural mass model(Springer-Verlag Berlin Heidelberg, 2012)In this work, we introduce the kinetic framework for modelling synaptic transmission in an existing neural mass model of the thalamocortical circuitry to study Electroencephalogram (EEG) slowing within the alpha frequency band (8–13 Hz), a hallmark of Alzheimer’s disease (AD). Ligand-gated excitatory and inhibitory synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and GABAA (gamma-amino-butyric acid) receptors respectively are modelled. Our results show that the concentration of the GABA neurotransmitter acts as a bifurcation parameter, causing the model to switch from a limit cycle mode to a steady state. Further, the retino-geniculate pathway connectivity plays a significant role in modulating the power within the alpha band, thus conforming to research proposing ocular biomarkers in AD. Overall, kinetic modelling of synaptic transmission in neural mass models has enabled a more detailed investigation into the neural correlates underlying abnormal EEG in AD.
Yaoundé-like virus in resident wild bird, Ghana(Academic journals, 2012-03-09)Tissue and swab samples from 551 wild birds collected in Ghana (October-November 2007) were assayed for alphaviruses, flaviviruses, and influenza A viruses using polymerase chain (PCR) techniques. One pool sample tested positive for Flavivirus RNA; further testing revealed that the amplified sequence was Yaoundé virus (YAOV), or closely related to it. YAOV is an apparently rare Flavivirus closely related to medically important human pathogens Japanese Encephalitis virus and West Nile virus. It is known only from West Africa. This is the first detection from Ghana, and only the second detection from a bird. Samples were negative for alphaviruses and Influenza A virus.
Avian influenza infections in non-migratant land birds in Andean Peru(Wildlife Disease Association, 2012-06-13)As part of ongoing surveillance for avian influenza viruses (AIV) in Peruvian birds, in June 2008, we sampled 600 land birds of 177 species, using real-time reverse-transcription PCR. We addressed the assumption that AIV prevalence is low or nil among land birds, a hypothesis that was not supported by the results—rather, we found AIV infections at relatively high prevalences in birds of the orders Apodiformes (hummingbirds) and Passeriformes (songbirds). Surveillance programs for monitoring spread and identification of AIV should thus not focus solely on water birds.
Liver disease presentation and red flags in urgent, primary and community care(2019-03-06)Liver Disease Presentations & Red Flags in Urgent, Primary & Community Care- Gerri Mortimore, Advanced Practice Lecturer, ANP Specialist & Expert Advisor for NICE
Validation of electrokinetic stabilisation of M5 Junction 7(ICE, 2019-01-07)Electrokinetic method has been increasingly applied to repair infrastructure earthwork involving landslip. The work presented in this paper attempts to improve the current understanding of this innovative technique by verifying the effectiveness of Electrokinetic treatment using in-situ and laboratory testing in addition to monitoring data obtained from the first full scale project implementing this technique, which has been carried out recently for a defected embankment slope on M5- Junction 7 in the UK. The paper outlines the design and implementation aspects of the project and discusses the findings of the post construction verification.