2.50
Hdl Handle:
http://hdl.handle.net/10545/302144
Title:
Evidence of melanoma in wild marine fish populations
Authors:
Sweet, Michael ( 0000-0003-4983-8333 ) ; Kirkham, Nigel; Bendall, Mark; Currey, Leanne; Bythell, John; Heupel, Michelle; Vartanian, Jean-Pierre
Abstract:
The increase in reports of novel diseases in a wide range of ecosystems, both terrestrial and marine, has been linked to many factors including exposure to novel pathogens and changes in the global climate. Prevalence of skin cancer in particular has been found to be increasing in humans, but has not been reported in wild fish before. Here we report extensive melanosis and melanoma (skin cancer) in wild populations of an iconic, commercially-important marine fish, the coral trout Plectropomus leopardus. The syndrome reported here has strong similarities to previous studies associated with UV induced melanomas in the well-established laboratory fish model Xiphophorus. Relatively high prevalence rates of this syndrome (15%) were recorded at two offshore sites in the Great Barrier Reef Marine Park (GBRMP). In the absence of microbial pathogens and given the strong similarities to the UV-induced melanomas, we conclude that the likely cause was environmental exposure to UV radiation. Further studies are needed to establish the large scale distribution of the syndrome and confirm that the lesions reported here are the same as the melanoma in Xiphophorus, by assessing mutation of the EGFR gene, Xmrk. Furthermore, research on the potential links of this syndrome to increases in UV radiation from stratospheric ozone depletion needs to be completed.
Citation:
Evidence of Melanoma in Wild Marine Fish Populations 2012, 7 (8):e41989 PLoS ONE
Journal:
PLoS ONE
Issue Date:
24-Sep-2013
URI:
http://hdl.handle.net/10545/302144
DOI:
10.1371/journal.pone.0041989
Additional Links:
http://dx.plos.org/10.1371/journal.pone.0041989
Type:
Research Report
ISSN:
1932-6203
Appears in Collections:
Biological Sciences Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorSweet, Michaelen
dc.contributor.authorKirkham, Nigelen
dc.contributor.authorBendall, Marken
dc.contributor.authorCurrey, Leanneen
dc.contributor.authorBythell, Johnen
dc.contributor.authorHeupel, Michelleen
dc.contributor.authorVartanian, Jean-Pierreen
dc.date.accessioned2013-09-24T08:19:09Z-
dc.date.available2013-09-24T08:19:09Z-
dc.date.issued2013-09-24-
dc.identifier.citationEvidence of Melanoma in Wild Marine Fish Populations 2012, 7 (8):e41989 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.doi10.1371/journal.pone.0041989-
dc.identifier.urihttp://hdl.handle.net/10545/302144-
dc.description.abstractThe increase in reports of novel diseases in a wide range of ecosystems, both terrestrial and marine, has been linked to many factors including exposure to novel pathogens and changes in the global climate. Prevalence of skin cancer in particular has been found to be increasing in humans, but has not been reported in wild fish before. Here we report extensive melanosis and melanoma (skin cancer) in wild populations of an iconic, commercially-important marine fish, the coral trout Plectropomus leopardus. The syndrome reported here has strong similarities to previous studies associated with UV induced melanomas in the well-established laboratory fish model Xiphophorus. Relatively high prevalence rates of this syndrome (15%) were recorded at two offshore sites in the Great Barrier Reef Marine Park (GBRMP). In the absence of microbial pathogens and given the strong similarities to the UV-induced melanomas, we conclude that the likely cause was environmental exposure to UV radiation. Further studies are needed to establish the large scale distribution of the syndrome and confirm that the lesions reported here are the same as the melanoma in Xiphophorus, by assessing mutation of the EGFR gene, Xmrk. Furthermore, research on the potential links of this syndrome to increases in UV radiation from stratospheric ozone depletion needs to be completed.en
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0041989en
dc.rightsArchived with thanks to PLoS ONEen
dc.titleEvidence of melanoma in wild marine fish populations-
dc.typeResearch Reporten
dc.identifier.journalPLoS ONEen
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